Structure and Intrinsic Disorder in Enzymology

Munishwar Nath Gupta,Vladimir N. Uversky

• Editorial: Academic Press
• Año: 2022
• ISBN:
  9780323995344
• Categoría: Sciences biologiques
• Categoría: Biophysique

Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more.

Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs.

• Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins
• Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study
• Features chapter contributions from international leaders in the field