The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle provides the first comprehensive overview on the molecular methodologies used to evaluate sleep while also examining the cellular, biochemical, genetic, and therapeutic aspects of the sleep-wake cycle. There have been profound changes in the landscape of approaches to the study of sleep â mainly in the areas of molecular biology and molecular techniques. With this great focus on using multidisciplinary molecular methods, chapters address significant advances in the molecular mechanisms underlying sleep and the techniques researchers use to study this phenomenon.
Written by world-leading experts in the area, this book is of great interest to researchers working in the sleep field and to anyone interested in one of the most mysterious phenomena in science â why we sleep and why we cannot survive without it.
Reviews the neurobiological and cellular mechanisms of the sleep-wake cycle
Provides the implications of sleep in health and disease
Contrasts different techniques to study molecular mechanisms
Contains case studies to better illustrate points
Covers sleep disturbance and health problems involved in sleep
Includes chapters on the ontogeny of sleep, along with multiple mechanisms for sleep generation
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Yes, you can access The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle by Eric Murillo-Rodriguez in PDF and/or ePUB format, as well as other popular books in Medicine & Physiology. We have over one million books available in our catalogue for you to explore.
Timothy Roehrs1,2 and Thomas Roth1,2, 1Sleep Disorders and Research Center, Henry Ford Health System, Detroit, MI, United States, 2Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, United States
Abstract
This chapter provides an overview of the sleepâwake cycle. We describe the nature of the electrophysiology of normal sleep and the two distinct sleep states, rapid eye movement (REM) and nonrapid eye movement (NREM). The differential endocrine, autonomic, respiratory, thermal physiology and regulation, and cognitive processing associated with REM and NREM are outlined. The interactive, but independent, control of sleep and wakefulness by homeostatic and circadian processes and the ultradian regulation of REM and NREM states within sleep is also outlined. We provide an overview of the specific neurobiological mechanisms that control sleep and wakefulness and the circadian mechanisms that control the daily timing of sleep and wakefulness. Finally, we briefly discuss some factors that alter the nature and characteristics of sleep and wakefulness.
The sleepâwake cycle in healthy humans is a 24-hour cycle composed of approximately one-third sleep and two-thirds wake. The sleepâwake cycle is under complex, interacting circadian and homeostatic processes. Within the 24-hour sleepâwake cycle is a 90â120 minutes ultradian cycle (basic rest activity cycle), most clearly evident during sleep, but also hypothesized as being present during wakefulness. Sleep and circadian bioscientists continue to amass information regarding the genetic and neurobiological mechanisms underlying the sleepâwake cycle with information about some of the basic features and mechanisms emerging, but there is much yet to be discovered.
Sleep is a vital behavior with the appetitive and essential nature of sleep clearly evident in a humanâs inability to maintain wakefulness for more than 2 or 3 days. As the state of sleep need progressively increases during periods of sustained wakefulness (i.e., sleep deprivation), brief microsleeps begin to intrude into wakefulness during ongoing behavior and during periods of inactivity. As sleep drive further increases it is expressed as longer episodes of unintended sleep (i.e., naps).1 This vital, compulsory nature of sleep is in contrast to oneâs ability to food or fluid deprive oneself to death.
Sleep is characterized by a stereotypic posture, minimal movement, reduced responsivity to stimuli, reversibility, and species-specific diurnal timing and duration. In humans, sleep is recognized behaviorally by recumbence and eye closure, but some mammals sleep with eyes open (e.g., cattle) or while standing (e.g., horse, elephant).2 The immobility of human sleep is relative in that sleep walking and talking occur in some human sleep disorders and among animals some fish swim in place and mammals move periodically. The sleep state can be differentiated from death, coma, and hibernation by the characteristics of arousability and rapid reversibility. Sensory (nonvisual) monitoring of both exogenous and endogenous stimulation continues during sleep such that, for example, the vital stimulus of hypoxemia arouses even a severely sleep deprived individual and parents arouse to the cry of their baby. Further, sensory discrimination occurs as the parent does not arouse to the cry of another baby whose cry is of a similar stimulus intensity. Among mammals the daily duration of sleep varies from 2 to 20 hours with that of humans being approximately 8 hours.3 Larger animals have less daily sleep; for example, elephants sleep about 3 hours per day, while the chipmunk sleeps about 16 hours. Sleep is very light or absent during migration or postpartum in some birds and fish and northern fur seals sleep with one half of the brain at a time. Sleep in adult humans, in many, but not all cultures, occurs as a single bout during the dark hours, while for various other mammals sleep occurs in multiple bouts and for some mammals sleep is linked to the light period.
Sleep scientists measure sleep electrophysiologically, as behavioral assessment of sleep and its intensity by testing arousability or reversibility is obtrusive and disruptive of the very state being assessed.4 Electrophysiological measures correlate well with behavioral observations, but they further reveal subtleties that are not apparent behaviorally and subjectively. For example, some sleep disorders are associated with brief (3â15 seconds) electroencephalographic (EEG) arousals of which the sleeping individual is unaware. The simultaneous recording of the EEG, the electrooculogram (EOG), and the electromyogram (EMG) are the accepted standard measures of sleep and waking and together these measures are termed polysomnography (PSG).4
1.2 Electrophysiology of Sleep: Polysomnography
Behind the closed eyes and relative behavioral quiescence of sleep is an active, complex, and highly organized process composed of two distinct brain states: nonrapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. As will be seen below this distinction goes much beyond the presence or absence of eye movements for which these two states are named. Fig. 1.1 depicts PSGs of wake NREM and REM sleep.
We describe the characteristics of a PSG (i.e., EEG, EOG, and EMG) of sleepâwake in detail. In contrast to the low voltage (10â30 ”V) and fast frequency (16â35 Hz) of activated wakefulness, the cortical EEG (C3/4-A1/2) of relaxed, eyes-closed wakefulness is characterized by increased voltage (20â40 ”V) and an 8â12 Hz frequency. During the transition to sleep, sometimes called drowsy sleep or transitional sleep, the EEG frequency becomes mixed while the voltage remains at the level of relaxed wakefulness. In NREM sleep EEG voltage is further increased and frequency is further slowed. When arousal threshold is highest, the EEG of NREM sleep has a 0.5â2.5 Hz frequency with voltages of 75 ”V and higher, which is termed slow wave sleep (SWS). The EMG, highest in wakefulness, is gradually reduced during NREM sleep, although limb and body movements occur periodically during NREM and there still is voluntary control of musculature.
The EOGs of wakefulness reveal REMs, which during the transition to NREM sleep (i.e., drowsy sleep) become slow and rolling. Importantly, the rolling eye movements mark the onset of the functional blindness that all humans experience during sleep. This contributes to the dangers of drowsy driving. The EOG becomes quiescent during NREM SWS. After the first 90â120 minutes of NREM sleep the healthy normal person enters REM sleep.
The EOG of REM sleep, for which this sleep state is named, is characterized by rapid conjugate eye movements. The cortical EEG of REM reverts to the low voltage, mixed frequency pattern of drowsy sleep. The second defining characteristic of REM sleep is its skeletal muscle atonia, which is reflected in the EMG achieving its lowest level of the 24-hour period. The skeletal muscle atonia of REM sleep occurs through a process of postsynaptic inhibition of motor neurons at the dorsal horn of the spinal cord. Another important feature of REM sleep is its tonic and phasic components. The tonic components of REM sleep are the persistent muscle atonia and the desynchronized EEG. The phasic components are intermittent and include bursts of eye movements occurring against a background of EOG quiescence. Coupled with the eye movement bursts are muscle twitches, typically involving peripheral muscles. These twitches are superimposed on the tonic muscle atonia of REM and probably reflect sympathetic drive breaking through the postsynaptic motor inhibition (see Section 1.3.1).
Fig. 1.2 illustrates the progression of sleep stages in a healthy young adult across an 8-hour sleep period. NREM and REM sleep alternate in 90- to 120-minute cycles with the predominance of NREM SWS occurring in the first 4 hours of the night and REM sleep occurring in the last 4 hours.5 Of note across the night the duration of NREM SWS episodes diminish, while the duration of REM sleep episodes increase. This differential distribution of sleep stages across the night is associated with the unique sleep stateâspecific physiological and cognitive function changes we will now describe.
Table of contents
Cover image
Title page
Table of Contents
Copyright
List of Contributors
Introduction
Chapter 1. The SleepâWake Cycle: An Overview
Chapter 2. Electrophysiological Correlates of the SleepâWake Cycle
Chapter 3. Physiological Mechanisms for the Control of Waking
Chapter 4. Neurochemistry and Pharmacology of Sleep
Chapter 5. The Role of Neuroglobin in Brain Function and SleepâWake Cycle