- 1,160 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
About This Book
This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.
Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.
- Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen
- Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis
- Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists
Frequently asked questions
Information
The History and Life Cycle of Toxoplasma gondii
Abstract
Keywords
Acknowledgements
1.1 Introduction
1.2 The Etiological Agent
1.3 Parasite Morphology and Life Cycle
1.3.1 Tachyzoites
A) Tachyzoites (arrowhead) in smear. Giemsa stain. Note nucleus dividing into two nuclei (arrow).
B) A small tissue cyst in smear stained with Giemsa and a silver stain. Note the silver-positive tissue cyst wall (arrow head) enclosing bradyzoites that have a terminal nucleus (arrow).
C) Tissue cyst in section, PAS. Note PAS-positive bradyzoites (arrow) enclosed in a thin PAS-negative cyst wall (arrowhead).
D) Unsporulated oocysts in cat faeces. Unstained.
1.3.2 Bradyzoite and Tissue Cysts
1.3.3 Enteroepithelial Asexual and Sexual Stages
Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface to the First Edition
- Preface to the Second Edition
- List of Contributors
- Chapter 1. The History and Life Cycle of Toxoplasma gondii
- Chapter 2. The Ultrastructure of Toxoplasma gondii
- Chapter 3. Molecular Epidemiology and Population Structure of Toxoplasma gondii
- Chapter 4. Human Toxoplasma Infection
- Chapter 5. Ocular Disease due to Toxoplasma gondii
- Chapter 6. Toxoplasmosis in Wild and Domestic Animals
- Chapter 7. Toxoplasma Animal Models and Therapeutics
- Chapter 8. Biochemistry and Metabolism of Toxoplasma gondii: Carbohydrates, Lipids and Nucleotides
- Chapter 9. The Apicoplast and Mitochondrion of Toxoplasma gondii
- Chapter 10. Calcium Storage and Homeostasis in Toxoplasma gondii
- Chapter 11. The Toxoplasma gondii Parasitophorous Vacuole Membrane: A Multifunctional Organelle in the Infected Cell
- Chapter 12. Toxoplasma Secretory Proteins and Their Roles in Cell Invasion and Intracellular Survival
- Chapter 13. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes
- Chapter 14. Interactions Between Toxoplasma Effectors and Host Immune Responses
- Chapter 15. Bradyzoite Development
- Chapter 16. Development and Application of Classical Genetics in Toxoplasma gondii
- Chapter 17. Genetic Manipulation of Toxoplasma gondii
- Chapter 18. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii
- Chapter 19. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae
- Chapter 20. Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and Other Apicomplexa
- Chapter 21. Toxoplasma gondii Chemical Biology
- Chapter 22. Proteomics of Toxoplasma gondii
- Chapter 23. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioural Consequences
- Chapter 24. Innate Immunity to Toxoplasma gondii
- Chapter 25. Adaptive Immunity and Genetics of the Host Immune Response
- Chapter 26. Vaccination against Toxoplasmosis: Current Status and Future Prospects
- Epilogue
- Index