Polymorphism in Pharmaceutical Solids

Harry G. Brittain, Harry G. Brittain

• Verlag: CRC Press
• Jahr: 2018
• ISBN:
  9781420073225
• Auflage: 2
• Thema: Medicina
• Thema: Farmacologia

Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism a

Inhaltsverzeichnis

• Front Cover
• Preface
• Contents
• Contributors
• PART I THERMODYNAMIC AND THEORETICAL ISSUES
• 1. Theory and Principles of Polymorphic Systems
• 2. Application of the Phase Rule to the Characterizationof Polymorphic and Solvatomorphic Systems
• 3. Computational Methodologies: Toward Crystal Structureand Polymorph Prediction
• PART II PREPARATIVE METHODS FOR POLYMORPHSAND SOLVATOMORPHS
• 4. Classical Methods of Preparation of Polymorphsand Alternative Solid Forms
• 5. Approaches to High-Throughput Physical FormScreening and Discovery
• PART III STRUCTURAL PROPERTIES OF POLYMORPHSAND SOLVATOMORPHS
• 6. Structural Aspects of Polymorphism
• 7. Structural Aspects of Solvatomorphic Systems
• 8. Pharmaceutical Co-crystals: A New Opportunityin Pharmaceutical Science for a Long-Known but Little-StudiedClass of Compounds
• PART IV CHARACTERIZATION METHODS FOR POLYMORPHSAND SOLVATOMORPHS
• 9. Thermoanalytical and Crystallographic Methods
• 10. Vibrational Spectroscopy
• 11. Solid-State Nuclear Magnetic Resonance Spectroscopy
• 12. Effects of Polymorphism and Solid-State Solvationon Solubility and Dissolution Rate
• PART V INTERCONVERSION OF POLYMORPHS AND SOLVATOMORPHS
• 13. Solid-State Phase Transformations
• 14. Effects of Pharmaceutical Processing on the Solid Formof Drug and Excipient Materials
• PART VI SPECIAL TOPICS RELATED TO POLYMORPHISMAND SOLVATOMORPHISM
• 15. Structural Aspects of Molecular Dissymmetry
• 16. Amorphous Solids
• Index