Developmental and Fetal Origins of Differences in Monozygotic Twins

From Genetics to Environmental Factors

Alexandra Matias,Isaac Blickstein

• Verlag: Academic Press
• Jahr: 2020
• ISBN:
  9780128203071
• Thema: Médecine
• Thema: Génétique en médecine

Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout.

• Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management
• Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis
• Features contributions from international experts in twin genetics and developmental biology

Inhaltsverzeichnis

• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• List of Contributors
• Foreword by Enrico Lopriore
• Foreword by Pedro Abrunhosa
• Acknowledgments
• Chapter 1. Introduction
• Chapter 2. Biology of monozygotic twinning
• Chapter 3. Mechanisms of discordance in monozygotic twins: why and when?
• Chapter 4. Monozygotic twins in history: enlightenment by mythology and ethnography
• Chapter 5. Genetics and epigenetics differences in monozygotic twins: the vision of the geneticist
• Chapter 6. Heterokaryotypic monozygotic twins
• Chapter 7. Differences in placentation in monochorionic twin pregnancies
• Chapter 8. Differences in growth: selective intrauterine growth restriction in monochorionic twins
• Chapter 9. Hemoglobin differences at birth in monochorionic twins
• Chapter 10. Differences in amniotic fluid in MZ twins
• Chapter 11. Twin-reversed arterial perfusion sequence: different identical twins
• Chapter 12. Major discordant anomalies in monozygotic twins: management and outcome
• Chapter 13. Congenital heart disease in monozygotic twins
• Chapter 14. Spotting the differences in the first trimester of pregnancy in MZ twins: the issue of aneuploidies and TTTS screening
• Chapter 15. Noninvasive prenatal screening in twin pregnancies
• Chapter 16. A new way to look at multiples: the power of image
• Chapter 17. Differences in monozygotic twins: the implications of diet and intestinal microbioma
• Chapter 18. Differences in development in monozygotic twins
• Chapter 19. Monozygotic twins: a personal as well as a criminal and jurisdictional approach
• Chapter 20. Monozygotic twin differences in perceived age
• Chapter 21. The environmental differences between twins in utero and their importance for downstream development: a need for standardized monitoring in obstetric research
• Chapter 22. Future perspectives
• Index