The Chemistry of Hyperpolarized Magnetic Resonance Probes

Eul Hyun Suh,Zoltan Kovacs

• Verlag: Academic Press
• Jahr: 2024
• ISBN:
  9780323918435
• Thema: Sciences physiques
• Thema: Spectroscopie et analyse du spectre

The Chemistry of Hyperpolarized Magnetic Resonance Probes, Volume Seven focuses on the chemical aspects of hyperpolarized NMR/MRI technology, with synthesis and characterizations of labeled compounds discussed from a practical point-of-view. A brief overview of the various hyperpolarization techniques are given, with the optimization of hyperpolarization conditions and the determination of critical parameters such as polarization level and T1 relaxation values described. A practical guide on the in vivo applications of hyperpolarized compounds in small animals is also included.

• Helps readers understand the structural features that determine the properties of HP-probes, such as chemical shift and relaxation times
• Aids readers in selecting stable isotope labeled probes for hyperpolarized NMR/MRI applications
• Teachers readers how to use the most appropriate synthetic methodology for the labeled probes
• Covers how to find the most suitable polarization technique (DNP, PHIP etc.) for the probe

Inhaltsverzeichnis

• Cover image
• Title page
• Table of Contents
• Advances in Magnetic Resonance Technology and Applications Series
• Copyright
• Preface
• Chapter 1. Hyperpolarized tracer design, synthesis, and characterization
• Chapter 2. Optimization of hyperpolarized NMR signals in dissolution dynamic nuclear polarization
• Chapter 3. The chemistry of parahydrogen induced polarization
• Chapter 4. Beyond 13C-pyruvate: Prospects for biomedical applications of alternative hyperpolarized probes and isotopes
• Chapter 5. Technical considerations of MRI methods for validating DNP probes in small animals
• Index