Prague, Czechoslovakia, August 29–September 3, 1982

Karel Bláha, Petr Maloň, Karel Bláha, Petr Maloň

• Verlag: De Gruyter
• Jahr: 2019
• ISBN:
  9783111694344
• Auflage: 1
• Thema: Ciencias físicas
• Thema: Química

Inhaltsverzeichnis

• Preface
• Contents
• European Peptide Committee and Programme Committee
• Honorary Committee and Organizing Committee
• Previous European Peptide Symposia
• List of Participants
• In Memoriam, Emil Taschner
• In Memoriam, Dieter Marquarding
• In Memoriam, Erhard Gross
• Plenary Lectures
• Recent Developments in the Chemistry and Biology of Cyclic Peptides
• Conformational Considerations in the Design of Highly Potent and Long-Acting Peptide Hormone Agonists and Antagonists
• Semisynthesis of Proteins and Peptides
• Further Application of the Aqueous-Organic Two-Phase Approach to Enzyme-Catalyzed Peptide-Synthesis
• Interactions of Lipid Bilayers with Corticotropin, Dynorphin, and Enkephalin Peptides
• Gramicidin A: From Structure Towards the Molecular Mechanism of Action
• Structural Comparisons of Retroenantiomeric Cyclic Hexapeptides
• Circular Dichroism and Conformation of Peptides Related to Oxytocin
• Synthesis of Peptides
• Methods of Protection
• Adaptation of Side Reactions for Peptide Synthesis
• A New Type of Reagents for the Liberation of free Amino Components
• The Application of Recently Developed Amino Protecting Groups in Peptide Synthesis
• Preparation of 4-Sulfobenzyl Esters and their Use in Peptide Synthesis
• The 2-Chloroethyl Group for Carboxyl Protection in Peptide Synthesis
• Some Properties of Amino Acid and Peptide Phenacyl Esters
• Temporary Substitution of Asparagine by Aspartic Acid in the Synthesis of Peptide Segments of Vasoactive Intestinal Peptide (VIP)
• Methods of Coupling
• Recycling of Excess Peptides from Fragment Condensations with Carbonyldiimidazole/1-Hydroxybenzotriazole Activation
• Fatty Acids as Additives Suppressing Racemization of Amino Acid Residues in Peptide Synthesis by the DCC Method
• HPLC as a Tool for the Investigation of Peptide Bond Formation
• Application of Phosphinic Acids to Peptide Synthesis
• A Reinvestigation of the Mixed Anhydride Method
• Do Acylamino Acid and Peptide Anhydrides Exist?
• First Results with New Reagents for Peptide Coupling
• Peptide Syntheses without Isolation of Intermediates Using Biphasic Solvent System
• Some Applications of the Curtius Rearrangement
• Heterodetic Bonds
• A New Method for the Selective Synthesis of Unsymmetrical Cystine Peptides
• A Controlled Synthesis of Cyclic Unsymmetrical Cystine Peptides Bearing Two S-S Bridges in the Ring
• Synthesis of Cysteine and Cystine Containing Peptides through 3-0-[N-Benzyloxycarbony 1-S-Acetamidomethyl- Cysteinyl] -Hydroxy-2-Phenylindenone
• Method of Cyclization of Carba Analogues of Oxytocin
• Synthesis of Isopeptides of Lysine as Fundamental Structural Units of Clavicepamines
• Synthesis of Leucine Enkephalin- and Aspartame Analogs Containing Thioamide Linkages at Specific Positions
• Synthesis on Polymeric Supports
• Synthetic Studies on the Cecropins
• Improved Syntheses of Substance P and Analogues on a Phenolic Resin Support
• Peptide Ionophores. Synthesis and Characterization of Cyclic Octa- and Decapeptides Containing Leucine and Proline
• Histone Model Peptide Synthetized by Solid Phase Fragment Condensation
• The Biomimetic Gel Phase Synthesis of the RNA-Polymerase II Inhibitor Peptide 6'-Deshydroxy-Amanullin
• Methodological Studies on Gel Phase Synthesis of the Arginine-Rich Propeptide Extension of Proalbumin
• Use of the Nbb-Resin and 4-Hydroxymethylphenoxymethyl- Resin in Solid Phase Peptide Synthesis
• Comparative Syntheses of an Octapeptide Using Continuous Flow (Column) and Conventional Polyamide Solid Phase Methods
• The Solid Phase Synthesis of Neurotensin and Related Peptides on Polydimethylacrylamide Resins
• Liquid-Phase Synthesis of Biologically Active Peptides on Easily Detachable Poly(Ethylene Glycol) Supports
• Synthesis of Individual Peptides
• Synthesis of Tuftsin under HPLC Control
• Synthesis of Tuftsin Analogs with Elongated Peptide Chain and a Possible Anticancer Activity
• Synthesis of an IgG Fragment Decapeptide and Preliminary Evaluation of its Role on Phagocytosis Stimulation of Human Polymorphonuclear Leukocytes
• Synthesis and Pharmacologic Characterization of Glucagon (1-21)-Peptide
• The Synthesis of Peptides Related to Prothrombin
• Total Synthesis of Neurotoxin II from the Central Asian Cobra (Naja naja oxiana) venom
• Synthesis of Labelled Peptides
• Catalytic Exchange Labelling of Peptides
• Solid Phase Synthesis of Neurotensin Analogues Susceptible to Radiolabelling
• Tritium Incorporation into Histidine by Direct Catalytic Exchange: Labelling of Gonadotropin Releasing Hormone and Analogs
• The ³H-Labelling of Peptides by Reduction of Dehydroleucine
• Analogues of [8-ArginineJ Vasopressin for Hormone Receptor Research
• Synthesis of Peptides Containing Non-Coded Amino Acids
• Synthetic Fragments of Bacterial Cell Walls. Physicochemical and Biological Properties
• Synthesis of Analogues of Precursors of Bacterial Peptidoglycan
• Synthesis of Peptides with α, β-Dehydroaminoacid Residue
• Synthesis of Dehydro Amino Acids and Peptides
• α-Hydroxymethylation of Peptides: A Synthetic Route to Peptides Containing α-Hydroxymethy1-Amino Acids
• L- α-Aminoadipic Acid δ-N-Benzyloxycarbonylamide and its Use in Peptide Synthesis
• Synthesis of ß-Homo-L-Proline Analogues of Peptide Hormones
• Optically Active Neopentylglycine and its Applications in Peptide Chemistry
• Monodisperse Conjugates of Catecholamines
• Total Synthesis of Althiomycin
• Peptide Tricyclic Thia-Cyclols from Linear Precursors
• Semi-Synthesis
• Synthesis of Cytochrome C-(66-104) Nonatriacontapeptide and Analogues
• Cytochrome c̱ Semisynthesis Using Enzymic Resynthesis Techniques
• Semisynthetic Analogs of Globomycin
• Semisynthetic Studies on the Bovine Trypsin-Kallikrein Inhibitor
• Synthesis of a Hybrid Chicken/Human Insulin
• Semisyntheses of Insulin Analogues by Replacement of the Sequence Al-4
• Synthesis of Peptides Using Enzymes
• Enzymatic Peptide Synthesis
• Amidation of Synthetic Peptides by Pituitary Enzyme: Specificity and Mechanism of the Reaction
• Reaction Mechanism in Trypsin Catalyzed Synthesis of Human Insulin Studied by ¹⁷O-NMR Spectroscopy
• Trypsin-Catalyzed Oligomerization of the Ala-Ala-Arg Tripeptide
• Thermitase-Catalyzed Hydrolysis of the C-Terminal Ester Group of Protected Peptide Ester Derivatives
• Reversibility of Tryptic Hydrolysis in a Model Nonapeptide Sequence
• Synthesis and Characterization of α- and/or ε-Substituted Lysine Peptides
• Purification, Characterization and Analytics
• Isolation by Preparative HPLC and Characterization of Major Components after Cyclization of a Decapeptide
• Separation of Basic, Hydrophilic Peptides by Reversed- Phase Ion-Pair Chromatography. III. A Progress Report
• Pre-Column Derivatization in HPLC of Peptides
• Fast Atom Bombardment Mass Spectrometry - a New Tool for Peptide Sequence Analysis
• Progress Towards a Post-Synthetic Chiral Analysis of Peptides
• Direct Peptide Sequencing after TLC on Silica Gel without Substance Elution
• Structure-Activity Relations
• Neurohypophyseal Hormones
• Two Analogues of Oxytocin with Modified Proline Cyclic Structure
• Synthesis of new Active and Highly Selective Analogues of Oxytocin and Arginine-Vasopressin
• CNS - Active Vasopressin Analogues
• Investigation of Position 2 and 3 of Vasopressins
• Analogues of Neurohypophysial Hormones Containing a D-Amino Acid in Position 2
• Penicillamine-Containing Analogues of Neurohypophysial Hormones
• 9-Substituted Vasopressin Analogs with Substantial Antidiuretic Activity
• Interactions of Deamino-6-Carba-0xytocin Analogues in Rat Kidney and Liver Membrane Systems
• Opioid Peptides
• Synthesis and Biological Activity of New Enkephalin Analogues
• Biochemical and Pharmacological Investigations of Peripheral and Brain δ-Opiate Receptors Using Tyr-D-Thr-Gly- Phe-Leu-Thr, a New Fully Specific 6-Ligand
• Double Opiate Peptides. A Hypothesis of Two Different Mechanisms of Opiate Actions
• Synthesis and Activity of Kyotorphin and its Analogs
• Opioid Activity of Synthetic "Small Demorphins"
• Structure-Activity Relationship of Dermorphin
• Structural Modifications of β-Casomorphin-5: Synthesis and Pharmacology
• Substance P
• Substance P: The "Yin-Yang" of Behavior?
• Hydrophilic Analogs of Substance P: Introduction of Sugar Acids and Sulfonium Groups
• Influence of the Methionine Sidechain on the Biological Activity of Substance P
• Substance P Analogues Containing Para-Substituted Phenylalanine: Synthesis and Pharmacological Properties
• Synthesis of Potent and Specific Antagonists of Substance P
• Substance P: Inactivation in CNS, Enzymatically Resistant Analogue and Development of "Brain Selective" Agonist
• Other Biologically Active Peptides
• Some Pharmaceutical Aspects of Peptide Research
• The Synthesis and Gonadotropic Activity of [D-Tle⁶, Pro-NH-Et⁹]LRF
• The Role of N-Acyl Groups in the Inhibitory Activity of LH-RH Analogues
• Gonadotropin Releasing Hormone and its Analogs Desensitize Pituitary GnRH Action
• DSIP: Novel Developments in Structure-Functional Studies
• The Active Centres of Gastrin and Cholecystokynin: Syntheses, Conformational Problems, Correlation between Chemical Structure and Biological Activity
• What is the Minimum Active Centre of Gastrin?
• Structure-Activity Relationships of Highly Potent and Specific Gctapeptide Analogues of Somatostatin
• Photoreactive [Leu⁹]-a-MSH Derivatives for Receptor Labelling
• Degradation of α-Melanotropin by the Enzymes of the Soluble Fraction of Rat Brain Homogenate
• Solid Phase Synthesis of Amunine (CRF), Sauvagine and Two Urotensin I
• Proctolin: Synthesis, Enzymatic Degradation and Effect on the Cyclic Nucleotide System
• Phosphonopeptides, Novel Inhibitors of Bacterial Cell Wall Biosynthesis
• Urinary Excretion of Biologically Active Peptides and/or Peptide-Like Material in Various Disorders
• Inhibitors and Binding Studies
• Synthesis and Properties of Peptide Ketones
• Enkephalin Diazomethyl and Chloromethyl Ketones: Synthesis and Biological Activity
• Use of Quantitative Lipophilicity Relationships for the Design of Renin Inhibitors
• Specific Inhibitors of Renin
• Anionic Inhibitors of Elastase
• Inhibition of Thrombin with H- and Boc-D-Phe-Pro-Agm
• Analogues of Chymostatin
• Binding Studies of Glucagon Antagonists
• Determination of the Toxic and Antigenic Sites of Peptide Snake Venom Short Neurotoxins
• Design and Synthesis of Two Peptides as Models for the Antigenic Sites of the Toxin II of the Scorpion Androctonus australis Hector
• Immunology Related Peptides
• Chemical Approaches to Improve Immunoassays of Peptide Hormones
• Antineoplastic and Immunogenic Effects of Tuftsin (Thr-Lys-Pro-Arg) and its Analogs
• Synthesis and Biological Assays of Peptides from a Tuberculin-Active Protein
• Synthesis and Immunoreactivity of Escherichia Coli Heat Stable Enterotoxins Analogs
• Preparation and Antigenicity of the C-Terminal Fragments of Human Leukocyte Interferons α2 and α1
• Immunological Properties of Hapten-Peptide Conjugates: The Effect of Size, Lipophilic Substituents and Haptenic Distance on Tolerogenicity and Anaphylactogenicity
• Conformational Studies
• Conformation: Model Peptides
• Conformational Features of Alternating L, D Peptides
• Conformation of Cyclic Hexapeptides Studied by the Modified Factor Analysis of Circular Dichroism Spectra
• Conformational Energy Calculations of Heterodetic Cyclic Hexapeptides Related to Oxytocin Ring Moiety
• Conformational Energy Analysis of Oxytocin Molecule
• Conformational Analysis of Peptides Substrate of N-Glycosylation
• Serine and ß-Folding
• X-Ray Structure and Conformation in Solution of Peptides Containing α-Aminoisobutyric Acid Residues
• Preferred Conformations of Host-Guest Peptides
• Conformation: Biologically Active Peptides
• Conformation Calculations and Biologically Active Conformations of Cyclopeptides
• Peptaibol Antibiotics: A Study on the Helical Structure of Emerimicins
• Conformational and Ionophoric Properties of Prolyl Containing Analogs of Valinomycin
• Synthesis of the Postulated Calcium Binding Site I of Calmodulin and Binding Studies
• X-Ray Structural Study of Ionophores of a Valinomycin Group
• Conformational Studies on Gaba-Enkephalinamides
• Conformational Studies of the "in vitro" Potent Opiate [D-Met², Trp⁴, Pro⁵] Enkephalinamide by Fluorescence and Theoretical Calculations
• Configuration of the Azo Bridge in Azo-Enkephalin
• Self-Association of Substance P and its C-Terminal Sequences
• Spatial Structure of Bradykinin Potentiating Peptide BPP_9α
• Guest-Host Relationship in Bradykinin Peptides
• Importance of Residue 5 in Antiotensin II
• Circular Dichroism Aids Interpretation of Structure- Activity Relationship of Somatostatin Analogs
• The Conformational Equilibrium of the Peptide Hormone Somatostatin and some Analogues in Aqueous Solution
• Application of Homonuclear and Heteronuclear Two-Dimensional NMR Spectroscopy to Cyclolinopeptide A (1)
• Role of the N-Terminal Fragment on the Stability of the Porcine Pancreatic Secretory Tryps in Inhibitors (KAZAL)
• Relationship between the Steric Structure of Insulin Derivatives and their Biological Activity
• Studies of Hydrogen Bonding in Relation to Oxytocin Activity
• Synthesis, Conformation and Interaction with a Decanucleotide of the Fragment (26-39) of the "Cro" Protein from Bacteriophage λ
• Abbreviations
• Subject Index
• Authors' Index