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Evidence-Based Validation of Herbal Medicine
Pulok K. Mukherjee
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eBook - ePub
Evidence-Based Validation of Herbal Medicine
Pulok K. Mukherjee
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Evidence-Based Validation of Herbal Medicines brings together current thinking and practice in the areas of characterization and validation of natural products. This book reviews all aspects of evaluation and development of medicines from plant sources, including their cultivation, collection, phytochemical and phyto-pharmacological evaluation, and therapeutic potential. Emphasis is placed on describing the full range of evidence-based analytical and bio-analytical techniques used to characterize natural products, including – omic technologies, phyto-chemical analysis, hyphenated techniques, and many more.
- Includes state-of-the-art methods for detecting, isolating, and performing structure elucidation by degradation and spectroscopic techniques
- Covers biosynthesis, synthesis, and biological activity related to natural products
- Consolidates information to save time and money in research
- Increases confidence levels in quality and validity of natural products
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MédecineCategoría
PharmacologieChapter 1
Quality Related Safety Issue-Evidence-Based Validation of Herbal Medicine Farm to Pharma
Pulok K. Mukherjee, Shiv Bahadur, Sushil K. Chaudhary, Amit Kar, and Kakali Mukherjee School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India
Abstract
Because of their unique effects and relatively low side effects, herbal medicine has been gaining popularity all over the world. Quality control is a challenge to ensure safety, efficacy, and batch-to-batch consistency of herbal products due to the complexity of phytochemical constituents. Generally, it is believed that the risk associated with herbal drugs is very less, but several reports on serious reactions are indicating the need for the development of safety profiles; effective regulatory guidelines; and quality control systems for authentication, isolation, and standardization of herbal medicine. Lack of strict guidelines on the assessment of safety and efficacy, quality control, safety monitoring, and knowledge on traditional medicine (TM) are the main aspects that are found in different regulatory systems. Proper validation of herbs used in TM needs to be done for their promotion and development.
Keywords
Herb–drug interaction; Marker profiling; Pharmacovigilance; Quality control; Safety evaluation; Standardization1.1. Health Care through Herbal Medicine
Herbal medicines attract the interest of both patients and scientists, in all aspects of drug development from natural products and also for validation of traditional medicine (TM). Several developing countries rely on TM because of their accessibility and affordability, and scientists all over the world consider medicinal plants as a source of new chemical entities and use them to isolate compounds such as digoxin, morphine, taxol, atropine, and vinblastine [1]. Herbal medicines have an important position in health care systems worldwide; their current assessment and quality control are a major bottleneck. Many adverse events of herbal medicines can be attributed to the poor quality of the raw materials or the finished products. Quality issues of herbal medicines can be classified into two categories, external and internal. External issues include toxic metals, pesticides residues, microbes, adulteration, and misidentification of medicinal plants. The internal issues affecting the quality of herbal medicines are complexity and nonuniformity of the ingredients. Through the use of modern analytical methods and pharmaceutical techniques, previously unsolved internal issues have become solvable [2]. The increasing search for therapeutic agents derived from plant species is justified by the emergence of diseases. Medicinal plants serve as the most valuable source for curing many diseases. Herbal medicines include herbal extracts, herbal drug preparations, and herbal drugs. Herbal drugs are unprocessed parts of plants or whole plants [3]. Herbs include crude plant material such as leaves, flowers, fruit, seed, stems, wood, bark, roots, rhizomes, or other plant parts, which may be entire, fragmented, or powdered. Herbal preparations include comminuted or powdered materials or extracts, tinctures, and fatty oils of herbal materials, which may be produced by extraction, fractionation, purification, concentration, or other physical or biological processes [4].
Modern allopathic medicine has developed from ancient medicine, and it is likely that many important new remedies were discovered and commercialized following the leads provided by traditional knowledge and experiences. The study of these traditions not only provides an insight into how the field has developed but it is also a fascinating example of our ability to develop a diversity of cultural practices [5]. The administering of a pure chemical or a plant extract containing the same chemical entity is essentially different. The difference is mainly due to the complexity of a plant extract that introduces many variables to conventional phytomedicinal research, which could possibly contribute to chemical complexity and bioactivity. On administration of plant material of Artemisia annua versus the pure drug, for example, artemisinin, showed that the bioavailability from the leaves was 45 times more than that of the pure drug [6]. Thus, the complexity of the plant extract could have contributed to the increased bioavailability and thus the bioactivity. A genuine interest on various traditional practices now exists among practitioners of modern medicine and a number of practitioners of traditional, indigenous, or alternative systems are beginning to accept and use som...
Índice
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Foreword
- Preface
- Acknowledgments
- Chapter 1. Quality Related Safety Issue-Evidence-Based Validation of Herbal Medicine Farm to Pharma
- Chapter 2. Value Chains of Herbal Medicines—Ethnopharmacological and Analytical Challenges in a Globalizing World
- Chapter 3. Traditional Herbal Medicine, Pharmacognosy, and Pharmacopoeial Standards: A Discussion at the Crossroads
- Chapter 4. Taxonomy—An Irreplaceable Tool for Validation of Herbal Medicine
- Chapter 5. Validation of Medicinal Herbs for Skin Aging
- Chapter 6. Proangiogenic Potential of Medicinal Plants in Wound Healing
- Chapter 7. Pharmacovigilance: Tools in Establishing the Safety and Acceptability of the Natural Health Products—Clinical Evaluation
- Chapter 8. Validation of Antiviral Potential of Herbal Ethnomedicine
- Chapter 9. Harmonization of Regulatory Requirements in Europe to Ensure Quality, Safety and Efficacy of Herbal Medicinal Products
- Chapter 10. Bioavailability of Herbal Products: Approach Toward Improved Pharmacokinetics
- Chapter 11. Good Quality and Clinical Practices for the Future Development of Herbal Medicines
- Chapter 12. Traditional Medicine-Inspired Evidence-Based Approaches to Drug Discovery
- Chapter 13. Evaluation of Bioactive Compounds as Acetylcholinesterase Inhibitors from Medicinal Plants
- Chapter 14. Drugs and Drug Leads Based on Natural Products for Treatment and Prophylaxis of Malaria
- Chapter 15. Evaluation of Natural Products against Biofilm-Mediated Bacterial Resistance
- Chapter 16. Clinical Effects of Caraway, a Traditional Medicine for Weight Loss
- Chapter 17. Challenges in Identification of Potential Phytotherapies from Contemporary Biomedical Literature
- Chapter 18. Botanicals as Medicinal Food and Their Effects against Obesity
- Chapter 19. Applications of High Performance Liquid Chromatography in the Analysis of Herbal Products
- Chapter 20. Ayurveda – Opportunities for Developing Safe and Effective Treatment Choices for the Future
- Chapter 21. Discovery and Development of Lead Compounds from Natural Sources Using Computational Approaches
- Chapter 22. Infrared Spectroscopic Technologies for the Quality Control of Herbal Medicines
- Chapter 23. Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay
- Chapter 24. Uses of Herbals in Cardiac Diseases: Priority of Evidence Over Belief
- Index
Estilos de citas para Evidence-Based Validation of Herbal Medicine
APA 6 Citation
[author missing]. (2015). Evidence-Based Validation of Herbal Medicine ([edition unavailable]). Elsevier Science. Retrieved from https://www.perlego.com/book/1832726/evidencebased-validation-of-herbal-medicine-pdf (Original work published 2015)
Chicago Citation
[author missing]. (2015) 2015. Evidence-Based Validation of Herbal Medicine. [Edition unavailable]. Elsevier Science. https://www.perlego.com/book/1832726/evidencebased-validation-of-herbal-medicine-pdf.
Harvard Citation
[author missing] (2015) Evidence-Based Validation of Herbal Medicine. [edition unavailable]. Elsevier Science. Available at: https://www.perlego.com/book/1832726/evidencebased-validation-of-herbal-medicine-pdf (Accessed: 15 October 2022).
MLA 7 Citation
[author missing]. Evidence-Based Validation of Herbal Medicine. [edition unavailable]. Elsevier Science, 2015. Web. 15 Oct. 2022.