Aptamers Engineered Nanocarriers for Cancer Therapy

Prashant Kesharwani

• Editorial: Woodhead Publishing
• Año: 2022
• ISBN:
  9780323855761
• Categoría: Technik & Maschinenbau
• Categoría: Werkstoffwissenschaft

Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers – such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available.

This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy.

• Reviews the mechanisms behind multi-drug resistance (MDR) in cancer and how aptamer-mediated novel therapeutic agents and strategies can facilitate MDR reversal
• Covers a range of aptamers engineered nanostructures, including PLGA nanoparticles, silica nanoparticles, quantum dots, nucleic acid aptamers, and more
• Discusses the challenges associated with using aptamers as cancer therapeutics and how this translates into clinical use

Índice

• Cover image
• Title page
• Table of Contents
• Copyright
• Contributors
• 1. Cell-SELEX technology for aptamer selection
• 2. Aptamers in biosensing: biological characteristics and applications
• 3. Mechanisms of multidrug resistance in cancer
• 4. Relevance of aptamers as targeting ligands for anticancer therapies
• 5. Aptamers as smart ligands for the development of cancer-targeting nanocarriers
• 6. Aptamer-functionalized liposomes for targeted cancer therapy
• 7. Aptamer-functionalized micelles for targeted cancer therapy
• 8. Aptamer-functionalized nanoparticles for targeted cancer therapy
• 9. Aptamer-functionalized PLGA nanoparticles for targeted cancer therapy
• 10. Aptamer-functionalized silicon nanoparticles for targeted cancer therapy
• 11. Aptamer-functionalized dendrimers for targeted cancer therapy
• 12. Aptamer-conjugated carbon nanotubes or graphene for targeted cancer therapy and diagnosis
• 13. Aptamer-functionalized quantum dots for targeted cancer therapy
• 14. Cancer immunotherapy via nucleic acid aptamers
• 15. Recent advances in aptamer-based nanomaterials in imaging and diagnostics of cancer
• 16. Microdevice-based aptamer sensors
• 17. Aptamer-based microfluidics for circulating tumor cells
• 18. Aptamer-based theranostic approaches for treatment of cancer
• 19. Challenges of aptamers as targeting ligands for anticancer therapies
• 20. Clinical use and future perspective of aptamers
• Index