Genome Plasticity in Health and Disease
- 288 pages
- English
- ePUB (adapté aux mobiles)
- Disponible sur iOS et Android
Genome Plasticity in Health and Disease
Ă propos de ce livre
Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing.
Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.
- Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders
- Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery
Foire aux questions
Informations
Table des matiĂšres
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1. Impact of genome plasticity on health and disease
- Section 1. Plasticity of the human genome
- Section 2. Human genome plasticity and diseases
- Index