The Chemical Biology of Phosphorus

Christopher T Walsh

• Éditeur: Royal Society of Chemistry
• Année: 2020
• ISBN:
  9781839162329
• Édition: 1
• Sujet: Scienze fisiche
• Sous-sujet: Chimica organica

Alexander Todd, the 1957 Nobel laureate in chemistry is credited with the statement: "where there is life, there is phosphorus". Phosphorus chemical biology underlies most of life's reactions and processes, from the covalent bonds that hold RNA and DNA together, to the making and spending 75 kg of ATP every day, required to run almost all metabolic and mechanical events in cells. Authored by a renowned biochemist, The Chemical Biology of Phosphorus provides an in-depth, unifying chemical approach to the logic and reactivity of inorganic phosphate and its three major derivatives (anhydrides, mono- and diesters) throughout biology to examine why life depends on phosphorus. Covering the breadth of phosphorus chemistry in biology, this book is ideal for biochemistry students, postgraduates and researchers interested in the chemical logic of phosphate metabolites, energy generation, biopolymer accumulation and phosphoproteomics.

Table des matières

• Cover
• Title
• Copyright
• Dedication
• Preface
• Contents
• Section I Introduction to Phosphorus and Inorganic Phosphates
• Chapter 1 Introduction to Phosphorus Chemical Biology
• Chapter 2 Inorganic Phosphate, Pyrophosphate, and Polyphosphate
• Section II ATP and Nucleoside Triphosphate Congeners: Substrates for Phosphoryl-, Pyrophosphoryl-, and Nucleotidyl Transferases
• Chapter 3 ATP as the Premier Biological Phosphoryl Transfer Reagent
• Chapter 4 Nucleotidyl Transfers (ATP and NTPs)
• Chapter 5 Pyrophosphoryl and Adenosyl Transfers from Mg–ATP
• Chapter 6 Activated Phosphoryl Groups and Biosynthetic Paths to ATP
• Chapter 7 Phosphomonoesters: Enzymatic Formation and Decomposition
• Section III Types of Phosphorylated Metabolites and Metabolic Logic
• Chapter 8 Phosphodiesters and Phosphotriesters
• Chapter 9 Phosphorylases: Inorganic Phosphate as Oxygen Nucleophile
• Chapter 10 N–P Bond Chemical Biology
• Chapter 11 C–P Bonds in Biology: Phosphonates and Phosphinates
• Chapter 12 P–S Bonds: Phosphorothioates
• Section IV Phosphoproteomics
• Chapter 13 Scope and Roles of Posttranslational Protein Phosphorylations
• Chapter 14 Noncanonical Phosphoproteomes
• Chapter 15 Canonical Phosphoproteomics: Phosphoserine, Phosphothreonine, and Phosphotyrosine
• Chapter 16 Noncanonical Phosphoproteomics – II
• Chapter 17 Broad Biological Arcs from Only Four Types of Phosphate Molecules
• Subject Index