Fungal Allergy and Pathogenicity

Renz, Breitenbach, Crameri, Lehrer

• Éditeur: S. Karger
• Année: 2002
• ISBN:
  9783318008302
• Édition: 1
• Sujet: Medicine
• Sous-sujet: Medical Microbiology & Parasitology

The importance of fungal organisms as allergens and pathogens has been increasing considerably over the last decade. This is due, on the one hand, to a general increase in the incidence of allergies, but also to the growing number of immunocompromized individuals such as AIDS patients or transplant recipients. This book summarizes what is currently known about the allergens of Candida, Aspergillus, Cladosporium, Alternaria, Coprinus, and Psilocybe, among others, and describes the application of recombinant allergens for diagnosis and new forms of therapy. The virulence factors and defense mechanisms against Aspergillus and Candida infections are discussed as are the various causes of superficial skin infections with fungi and the aerobiology of fungal spores and mycelia. A comprehensive chapter on fungal toxins and their importance for human and animal health is included, followed by a summary of the present state of fungal genome sequencing. Finally, the now generally accepted new sequence-based systematics and phylogeny of allergenic and pathogenic fungi is presented. A glossary explains the highly specialized terminology of clinical and systematic mycology for the nonspecialist. Summarizing the most up-to-date molecular and clinical findings, this publication will be of interest not only to allergologists, mycologists and biologists, but to all clinicians who want to learn more about clinically important fungi as well as to lawyers concerned with lawsuits on 'sick building syndrome'.

Table des matières

• Contents
• Foreword
• Introduction
• Impact of Current Genome Projects on the Study of Pathogenic and Allergenic Fungi
• Fungal Aerobiology: Exposure and Measurement
• Allergy to Basidiomycetes
• The Allergens of Cladosporium herbarum and Alternaria alternata
• Molecular Cloning of Aspergillus fumigatus Allergens and Their Role in Allergic Bronchopulmonary Aspergillosis
• Defense Mechanisms of the Airways against Aspergillus fumigatus: Role in Invasive Aspergillosis
• Secreted Proteinases and Other Virulence Mechanisms of Candida albicans
• Cutaneous Mycology
• Toxins of Filamentous Fungi
• Phylogeny and Systematics of the Fungi with Special Reference to the Ascomycota and Basidiomycota
• Glossary
• Author Index
• Subject Index