Mast Cells in Allergic Diseases

Renz, Saito, Okayama

• Éditeur: S. Karger
• Année: 2005
• ISBN:
  9783318012323
• Édition: 1
• Sujet: Medicina
• Sous-sujet: Farmacología

The discovery of IgE and its association with mast cell histamine release provided the initial understanding of the role of mast cells in asthma and acute allergic reactions. However, mast cells are now recognized as tissue-dwelling effector cells that play multiple roles not only in immediate-type allergic reaction but also in innate immunity, inflammation, angiogenesis, and tissue remodeling. Mast cells produce a variety of lipid mediators, chemokines, cytokines, and enzymes that may interact with inflammatory tissues such as asthmatic lungs. This book focuses on the roles of mast cell products in allergic diseases and discusses strategies to regulate mast cell functions without perturbing their physiological roles. It also aims at understanding mast cells at the system level by creating a detailed model of cell regulation which is expected to lead to highly mast cell-specific, i.e. efficient and safe, drug targets. Allergologists, immunologists and pharmacologists interested in developing new drugs for allergies will benefit from these timely reviews.

Table des matières

• Cover
• Contents
• Preface
• Regulation of Mast Cell Development
• Regulation of Mast Cell Activation through FcepsilonRI
• Role of Oxidants in Mast Cell Activation
• Roles of Adaptor Molecules in Mast Cell Activation
• Eicosanoid Mediators of Mast Cells: Receptors, Regulation of Synthesis, and Pathobiologic Implications
• Role of Mast Cell Proteases in Tissue Remodeling
• Mast Cell Mediators in Airway Remodeling
• Mast Cell-Derived Cytokine Expression Induced via Fc Receptors and Toll-Like Receptors
• Mast Cells in Allergic Airway Disease and Chronic Rhinosinusitis
• Chemokine Receptor Expression by Mast Cells
• Mast Cell beta2-Adrenoceptors
• Potential Role of Stem Cell Factor in the Asthma Control by Glucocorticoids
• Mast Cell Ion Channels
• Using Mast Cell Knock-In Mice to Analyze the Roles of Mast Cells in Allergic Responses in vivo
• Mast Cell-Specific Genes – New Drug Targets/ Pathogenesis
• Author Index
• Subject Index