Structural Aspects of Protein Synthesis

Anders Liljas, Måns Ehrenberg

• Éditeur: WSPC
• Année: 2013
• ISBN:
  9789814531801
• Édition: 2
• Sujet: Scienze biologiche
• Sous-sujet: Biochimica

This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases.

Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation.

There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.

Contents:

• The Basics of Translation
• Historical Milestones
• Methods of Studying Structure
• The Message — mRNA
• The Adaptor — tRNA
• The Workbench — Ribosomes
• The Structure of the Ribosome
• Ribosomal Sites and Ribosomal States
• The Catalysts — Translation Factors
• Inhibitors of Protein Synthesis — Antibiotics, Resistance
• The Process — Translation
• Protein Processing, Folding and Targeting
• Evolution of the Translation Apparatus

Readership: Upper level undergraduates and graduate students with an interest in protein synthesis; researchers in cell and molecular biology, biochemistry and biophysics who need to get an overview of translation.

Table des matières

• Front Cover
• Half Title
• Title Page
• Copyright
• Dedication
• Preface
• Content
• Chapter 1: The Basics of Translation
• Chapter 2: Historical Milestones
• Chapter 3: Methods of Studying Structure
• Chapter 4: The Message — mRNA
• Chapter 5: The Adaptor — tRNA
• Chapter 6: The Workbench — Ribosomes
• Chapter 7: The Structure of the Ribosome
• Chapter 8: Ribosomal Sites and Ribosomal States
• Chapter 9: The Catalysts — Translation Factors
• Chapter 10: Inhibitors of Protein Synthesis — Antibiotics, Resistance
• Chapter 11: The Process —Translation
• Chapter 12: Protein Processing, Folding and Targeting
• Chapter 13: Evolution of the Translation Apparatus
• Appendix I
• Appendix II
• References
• Index