Stem Cell and Tissue Engineering

Bone, Cartilage, and Associated Joint Tissue Defects

Krishna Pramanik

• Editore: CRC Press
• Anno: 2024
• ISBN:
  9781000999501
• Edizione: 1
• Argomento: Technologie et ingénierie
• Categoria: Sciences biomédicales

This book covers conventional clinical treatment methods for handling bone, cartilage, and related disorders along with their limitations and highlights the current state of the art of tissue engineering as an alternative for regenerating such defective tissue. Potential biomimetic scaffolding materials and their development, desired properties, modifications, and optimizations are described. The design and advancement in fabrication, characterization, properties, and biological functions of scaffolds, their integration with stem cells, and various bioreactor systems for tissue regeneration are presented. It further reviews in vitro and in vivo (pre-clinical) assessments of tissue constructs, involved translational challenges, and strategies in various stages of neo-tissue production.

Features:

• Discusses the key aspects of generating engineered bone, cartilage, and associated tissues through tissue engineering approach
• Describes multiple engineering principles, and processes involved in the various stages of developing biomaterials and scaffolds
• Covers integration of stem cells with scaffolds, including assessment of tissue grafts, and translational strategy
• Explores key factors influencing tissue graft generation in bioreactors and challenges involved in various stages
• Includes several exercises including review questions and numerical problems for better understanding of the subject

This book is aimed at researchers, students, and professionals in biomedical engineering, tissue engineering, stem cells, biomaterials, and orthopaedics.

Indice dei contenuti

• Cover
• Half-Title Page
• Title Page
• Copyright Page
• Table of Contents
• About the Author
• 1 Basic Biology of Bone, Cartilage, and Surrounding Tissues
• 2 Tissue Engineering as an Alternative Approach
• 3 Biomaterials for Repairing Bone, Cartilage, and Associated Joint Tissue Defects
• 4 Advances in Fabrication of Tissue Scaffolds
• 5 Scaffold Properties and Characterization
• 6 Stem Cells for Cartilage, Bone, and Related Tissue Regeneration
• 7 Bioreactor and Tissue Graft Generation
• 8 In Vitro Assessment of Engineered Bone and Cartilage Tissue Grafts
• 9 In Vivo Assessment of Regenerated Bone, Cartilage, and Joint Tissue
• 10 Translational Approaches and Regulatory Aspects
• Index