Mass Spectrometry for Drug Discovery and Drug Development
eBook - ePub

Mass Spectrometry for Drug Discovery and Drug Development

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eBook - ePub

Mass Spectrometry for Drug Discovery and Drug Development

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About This Book

Facilitates the discovery and development of new, effective therapeutics

With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics.

Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers:

  • HPLC–high-resolution mass spectrometry for quantitative assays
  • Mass spectrometry for siRNA
  • Quantitative analysis of peptides
  • Mass spectrometry analysis of biological drugs
  • Applications that support medicinal chemistry investigations
  • Mass spectrometry imaging and profiling

Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field.

Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

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Yes, you can access Mass Spectrometry for Drug Discovery and Drug Development by Walter A. Korfmacher in PDF and/or ePUB format, as well as other popular books in Physical Sciences & Analytic Chemistry. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Wiley
Year
2012
ISBN
9781118516140
Edition
1
Topic
Physical Sciences
Subtopic
Analytic Chemistry

Table of contents

  1. COVER
  2. WILEY SERIES ON MASS SPECTROMETRY
  3. TITLE PAGE
  4. COPYRIGHT PAGE
  5. DEDICATION
  6. CONTRIBUTORS
  7. PREFACE
  8. 1 OVERVIEW OF THE VARIOUS TYPES OF MASS SPECTROMETERS THAT ARE USED IN DRUG DISCOVERY AND DRUG DEVELOPMENT
  9. 2 UTILITY OF HIGH-RESOLUTION MASS SPECTROMETRY FOR NEW DRUG DISCOVERY APPLICATIONS
  10. 3 QUANTITATIVE MASS SPECTROMETRY CONSIDERATIONS IN A REGULATED ENVIRONMENT
  11. 4 MASS SPECTROMETRY FOR QUANTITATIVE IN VITRO ADME ASSAYS
  12. 5 METABOLITE IDENTIFICATION USING MASS SPECTROMETRY IN DRUG DEVELOPMENT
  13. 6 MS ANALYSIS OF BIOLOGICAL DRUGS, PROTEINS, AND PEPTIDES
  14. 7 CHARACTERIZATION OF IMPURITIES AND DEGRADATION PRODUCTS IN SMALL MOLECULE PHARMACEUTICALS AND BIOLOGICS
  15. 8 LIQUID EXTRACTION SURFACE ANALYSIS (LESA): A NEW MASS SPECTROMETRY-BASED TECHNIQUE FOR AMBIENT SURFACE PROFILING
  16. 9 MS APPLICATIONS IN SUPPORT OF MEDICINAL CHEMISTRY SCIENCES
  17. 10 IMAGING MASS SPECTROMETRY OF PROTEINS AND PEPTIDES
  18. 11 IMAGING MASS SPECTROMETRY FOR DRUGS AND METABOLITES
  19. 12 SCREENING REACTIVE METABOLITES: ROLE OF LIQUID CHROMATOGRAPHY–HIGH-RESOLUTION MASS SPECTROMETRY IN COMBINATION WITH “INTELLIGENT” DATA MINING TOOLS
  20. 13 MASS SPECTROMETRY OF SIRNA
  21. 14 MASS SPECTROMETRY FOR METABOLOMICS
  22. 15 QUANTITATIVE ANALYSIS OF PEPTIDES WITH MASS SPECTROMETRY: SELECTED REACTION MONITORING OR HIGH-RESOLUTION FULL SCAN?
  23. INDEX