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Antibacterial Agents
Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications
Rosaleen Anderson, Paul W. Groundwater, Adam Todd, Alan Worsley
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Antibacterial Agents
Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications
Rosaleen Anderson, Paul W. Groundwater, Adam Todd, Alan Worsley
About This Book
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated "lab-to-clinic" approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include:
- agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents
- agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim
- agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
- agents targeting cell wall synthesis - ?-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin
Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
Frequently asked questions
Information
- Bacteria can be classified according to their staining by the Gram stain (Gram positive, Gram negative, and mycobacteria) and their shape.
- Most bacterial (prokaryotic) cells differ from mammalian (eukaryotic) cells in that they have a cell wall and cell membrane, have no nucleus or organelles, and have different biochemistry.
- Bacteria can be identified by microscopy, or by using chromogenic (or fluorogenic) media or molecular diagnostic methods (e.g. real-time polymerase chain reaction (PCR)).
- Bacterial resistance to an antibacterial agent can occur as the result of alterations to a target enzyme or protein, alterations to the drug structure, and alterations to an efflux pump or porin.
- Antibiotic stewardship programmes are designed to optimise antimicrobial prescribing in order to improve individual patient care and slow the spread of antimicrobial resistance.
1.1.1 Classification
![img](https://book-extracts.perlego.com/1000436/images/nfg001-plgo-compressed.webp)
![img](https://book-extracts.perlego.com/1000436/images/nfg002-plgo-compressed.webp)
Gram positive | Gram negative | Mycobacteria |
Bacillus subtilis | Burkholderia cenocepacia | Mycobacterium africanum |
Enterococcus faecalis | Citrobacter freundii | Mycobacterium avium complex (MAC) |
Enterococcus faecium | Enterobacter cloacae | Mycobacterium bovis |
Staphylococcus epidermis | Escherichia coli | Mycobacterium leprae |
Staphylococcus aureus | Morganella morganii | Mycobacterium tuberculosis |
Meticillin-resistant Staphylococcus aureus (MRSA) | Pseudomonas aeruginosa | |
Streptococcus pyogenes | Salmonella typhimurium | |
Listeria monocytogenes | Yersinia enterocolitica |
1.1.2 Structure
- Bacteria have a cell wall and plasma membrane (the cell wall protects the bacteria from differences in osmotic pressure and prevents swelling and bursting due to the flow of water into the cell, which would occur as a result of the high intracellular salt concentration). The plasma membrane surrounds the cytoplasm and between it and the cell wall is the periplasmic space. Surrounding the cell wall, there is often a capsule (there is also an outer membrane layer in Gram negative bacteria). Mammalian eukaryotic cells only have a cell membrane, whereas the eukaryotic cells of plants and fungi also have cell walls.
- Bacterial cells do not have defined nuclei (in bacteria the DNA is present as a circular double-stranded coil in a region called the ânucleoidâ, as well as in circular DNA plasmids), are relatively simple, and do not contain organelles, whereas eukaryotic cells have nuclei containing the genetic information, are complex, and contain organelles,2 such as lysosomes.
- The biochemistry of bacterial cells is very different to that of eukaryotic cells. For example, bacteria synthesise their own folic acid (vitamin B9), which is used in the generation of the enzyme co-factors required in the biosynthesis of the DNA bases, while mammalian cells are incapable of folic acid synthesis and mammals must acquire this vitamin from their diet.
![img](https://book-extracts.perlego.com/1000436/images/nfg003-plgo-compressed.webp)
1.1.3 Antibacterial targets
1.1.3.1 DNA Replication
- The separation of the two strands at the origin to...
Table of contents
- Cover
- Title Page
- Copyright
- Dedication
- Preface
- Section 1: Introduction to Microorganisms and Antibacterial Chemotherapy
- Section 2: Agents Targeting DNA
- Section 3: Agents Targeting Metabolic Processes
- Section 4: Agents Targeting Protein Synthesis
- Section 5: Agents Targeting Cell-wall Synthesis
- Index