Concerns about the adverse health effects of chemicals and radiation present in the environment and at workplaces have created the need for better detection systems to assess their potential to cause DNA damage in humans and other organisms across ecosystems. The Micronucleus Assay in Toxicology is the first comprehensive volume concerning the use of micronucleus assays in genetic toxicology. It succinctly explains the mechanisms by which genotoxins cause micronucleus formation and its relation to diseases. Furthermore, it describes the methods which are currently used for the analyses of micronuclei in different types of cells in human in vivo biomonitoring studies, routine in vivo tests with rodents, in vitro studies with human and mammalian cells, environmental monitoring with invertebrates and vertebrates such as molluscs, fish and, also, in plant bioassays. Moreover, this book also focuses on the use of the micronucleus technique in other research areas, including the detection of DNA damage caused by important groups of genotoxic carcinogens (heavy metals, industrial chemicals, cytotoxic drugs, pesticides, ionising radiation, etc.) as well as study designs, statistical analyses, international regulatory guidelines, and the development of automated scoring devices for this assay. This book will serve as both, a reference and a guide to students, and investigators in biomedical, biochemical and pharmaceutical sciences interested in gaining a better understanding of the biology of micronuclei and their application in measuring DNA damage caused by natural or man-made genotoxins.

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Yes, you can access The Micronucleus Assay in Toxicology by Siegfried Knasmüller, Michael Fenech, Tim Marrs, Michael D Waters in PDF and/or ePUB format, as well as other popular books in Physical Sciences & Chemistry. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Royal Society of Chemistry

Year

2019

ISBN

9781788018494

Edition

Topic

Physical Sciences

Subtopic

Chemistry

Index

Chemistry

Cover
Halftitle
Series Editor
Title
Copyright
Preface
Contents
Section 1 The Origins of Micronuclei and their Association with Disease
Section 2: The In Vitro and In Vivo Application of Micronucleus Assays Using Cells From Humans, Rodents and Other Species
Section 3: Micronucleus Assays and Their Application to Study DNA Damage Induced by In Vivo Exposure to Genotoxins in Humans
Subject Index