Chemical Biology of Natural Products

David J. Newman, Gordon M. Cragg, Paul Grothaus

• Publisher: CRC Press
• Year: 2017
• ISBN:
  9781351643283
• Edition: 1
• Topic: Medicina
• Subtopic: Farmacología

Chemical Biology of Natural Products
This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds.

Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes.

Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Table of contents

• Cover
• Halftitle Page
• Title Page
• Copyright Page
• Contents
• Preface
• Editors
• Contributors
• Chapter 1 Microbial Genome Mining for Natural Product Drug Discovery
• Chapter 2 Chemical Biology of Marine Cyanobacteria
• Chapter 3 The Role of Combinatorial Biosynthesis in Natural Products Discovery
• Chapter 4 Generation of New-to-Nature Natural Products through Synthesis and Biosynthesis: Blending Synthetic Biology with Synthetic Chemistry
• Chapter 5 Terrestrial Microbial Natural Products Discovery Guided by Symbiotic Interactions and Revealed by Advanced Analytical Methods
• Chapter 6 Natural Products from Endophytic Microbes: Historical Perspectives, Prospects, and Guidance
• Chapter 7 Novel Insights in Plant–Endophyte Interactions
• Chapter 8 Microbial Coculture and OSMAC Approach as Strategies to Induce Cryptic Fungal Biogenetic Gene Clusters
• Chapter 9 Natural Products of the Rhizosphere and Its Microorganisms: Bioactivities and Implications of Occurrence
• Chapter 10 Novel Metabolites from Extremophilic Microbes Isolated from Toxic Waste Sites
• Chapter 11 Deep-Sea Hydrothermal Vent Organisms as Sources of Natural Products
• Chapter 12 Cone Snail Venom Peptides and Future Biomedical Applications of Natural Products
• Chapter 13 Naturally Occurring Disulfide-Rich Cyclic Peptides from Plants and Animals: Synthesis and Biosynthesis
• Chapter 14 Synthesis and Target Identification of Natural Product–Inspired Compound Collections
• Chapter 15 On the Chemistry and Biology of the Marine Macrolides Zampanolide and Dactylolide
• Index