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- 737 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
Early Phase Drug Evaluation in Man
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About This Book
Early Phase Drug Evaluation in Man is a comprehensive, practical guide that covers pre-clinical information relevant to early human studies, including pharmaceutical, metabolic, toxicological, and regulatory aspects, as well as the general considerations relevant to all early human studies. Each major therapeutic area is considered by class of activity of drug. The chapters describe what measurements of drug activity are available in healthy human subjects and in patients, how to make the measurements, their value and their limitations. The contributors have been drawn internationally from the pharmaceutical industry and academia. Early Phase Drug Evaluation in Man will provide an important reference guide for industry and academic professionals involved in the development of new drugs.
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Yes, you can access Early Phase Drug Evaluation in Man by John O'Grady, Otto I Linet in PDF and/or ePUB format, as well as other popular books in Medicine & Medical Theory, Practice & Reference. We have over one million books available in our catalogue for you to explore.
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Index
Abortifacient drugs 521–531
acceptability of treatment 528–529
definition of study population 522–523
evaluation of treatment outcome
efficacy 526–527
side–effects and complications 527–528
interaction with other drugs 528
mode of action 523–525
oxytocics 540–542
Abortion
clinical evaluation of oxytocic drugs in 540–542 see also Abortifacient drugs
Absorption of drugs 30–32
antidiabetics 618–619
assessment of 31–32
application of drugs into large bowel during colonoscopy 466–467
buccal absorption 467
HF capsule 466
intubation techniques 465–466
patients with artificial stoma 467
factors affecting 31
Abuse potential, anxiolytics 417–418
Academic research, ethics of patient studies 156
Adolescent acne, drug treatment of
clinical response 559
measurement of sebum excretion rate 559
Adverse effects, see Tolerance and side–effects
Age
and Phase I testing of antihypertensive drugs 306–307
and testing of anti-asthmatic drugs 367
AIDS research, ethics of 157
Alcohol consumption, and Phase I testing of antihypertensive drugs 308
Analgesics 558, 689–701
early studies of efficacy in patients 693–697
recommendations 697
useful paradigms for novel analgesics 694–697
acute pain 694–695
chronic pain 695–696
ethical considerations 689
later clinical
pharmacological
studies 698
studies of efficacy in volunteers ...
Table of contents
- Cover
- Half Title
- Title Page
- Copyright Page
- Table of Contents
- Foreword
- Preface
- I. Preliminaries to Testing of Drugs in Man
- II. Organisation and Decision Making
- III. Ethical and Legal Considerations
- IV. Measuring Drug Activity in Man
- V. Assessment of Drug Effects on the Cardiovascular System
- VI. Assessment of Drug Effects on the Respiratory System
- VII. Assessment of Drug Effects on the Central Nervous System
- VIII. Assessment of Drug Effects on the Gastro-intestinal System
- IX. Assessment of Drug Effects on the Kidney
- X. Assessment of the Effects of Drugs Used in Obstetrics and Gynaecology
- XI. Assessment of Drug Activity in the Skin
- XII. Assessment of Drugs Used for the Treatment of Metabolic Disorders
- XIII. Assessment of the Effects of Chemotherapeutic Agents
- XIV. Assessment of Drugs Affecting the Inflammatory Process and Pain
- Index