- 328 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Calcium Entry Channels in Non-Excitable Cells
About This Book
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
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Information
1
Electrophysiological Methods for Recording CRAC and TRPV5/6 Channels
1.1Introduction
1.2Characteristics of Calcium Entry in Non-excitable Cells
Table of contents
- Cover
- Halftitle Page
- Series Page
- Title Page
- Copyright Page
- Contents
- Series Preface
- Preface
- Contributors
- 1 Electrophysiological Methods for Recording CRAC and TRPV5/6 Channels
- 2 Studies of StructureāFunction and Subunit Composition of Orai/STIM Channel
- 3 Signaling ER Store Depletion to Plasma Membrane Orai Channels
- 4 Modulation of Orai1 and STIM1 by Cellular Factors
- 5 CRAC Channels and Ca2+-Dependent Gene Expression
- 6 Function of Orai/Stim Proteins Studied in Transgenic Animal Models
- 7 Assessing the Molecular Nature of the STIM1/Orai1 Coupling Interface Using FRET Approaches
- 8 Optogenetic Approaches to Control Calcium Entry in Non-Excitable Cells
- 9 Regulation of Orai/STIM Channels by pH
- 10 Non-Orai Partners of STIM Proteins
- 11 Store-Independent Orai Channels Regulated by STIM
- 12 Regulation and Role of Store-Operated Ca2+ Entry in Cellular Proliferation
- 13 TRPV5 and TRPV6 Calcium-Selective Channels
- 14 Determining the Crystal Structure of TRPV6
- 15 Identifying TRP Channel Subunit Stoichiometry Using Combined Single Channel Single Molecule Determinations (SC-SMD)
- 16 Pharmacology of Store-Operated Calcium Entry Channels
- Index