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- 279 pages
- English
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The Chemistry of PCB'S
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About This Book
The literature on chlorinated biphenyl is growing rapidly. Review articles on PCB's cited in this book usually contained a section on the toxicity of PCB. The structure and nomenclature are detailed. The chapters and topics included are (1) commercial PCB preparations: properties and compositions, (2) synthesis of chlorobiphenyls, (3) chemical reactions of chlorobiphenyls, (4) photodegradation of chlorobiphenyls, (5) metabolism of chlorobiphenyls, (5) mass spectroscopy of chlorobiphenyls, (6) nuclear magnetic resonance of chlorobiphenyls, (7) ultraviolet spectroscopy of chlorobiphenyls, (8) infrared spectrometry of chlorobiphenyls, (9) determination of chlorobiphenyls, and (10) recent developments.
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Chapter 1
INTRODUCTION
Historical and Literature
Chlorinated biphenyls were known before the turn of the century and the useful industrial properties of mixtures obtained by chlorination of biphenyl were recognized early (cf. 77). From a purely chemical point of view, the chlorobiphenyls are a rather unattractive class of compounds and limited attention was paid to them by the scientific community. In 1966, a note in the New Scientist about the discovery of the widespread occurrence of chlorinated biphenyls in the Swedish environment (Figure 1) and the following events were responsible for the truly dramatic upsurge of interest in these compounds.3, 46 In 1967, Widmark reported mass spectroscopic data as unambiguous proof of the chemical nature of these new contaminants106 and at about the same time PCBâs were found in various parts of the world.42, 43, 54, 56, 81
Even before the reports mentioned above, analysis were aware of âspurious peaksâ in electron capture gas chromatography which did not correspond to any of the known chlorinated pesticides.37, 41, 92, 93, 105 These peaks corresponding to components of PCB are not separated well under GC conditions usually used in pesticide analysis (Figures 2 and 3) and it is quite likely that many reports gave falsely high results for some pesticide residues (cf. 55).
It is now established that because of chemical properties (lipid solubility and resistance to degradation) PCBâs accumulate in food chains and are distributed worldwide, similar to the chlorinated pesticides such as DDT.
The literature on chlorinated biphenyl is growing rapidly and a number of reviews on various aspects of the problem are available. Generally, chlorinated biphenyls have been discussed in the context of chlorinated pesticides32, 54, 66, 91 and specifically.9, 22, 23, 24, 34, 44, 75, 76, 90, 100, 108, 109) A bibliography (to 1971) of articles dealing with chlorobiphenyls has been published83 and useful information can be obtained from conference reports,4, 26, 33 a review of the Panel on Hazardous Trace Substances,73 a recent Monsanto report,68 and a mimeographed publication PCB Newsletter,96 Analytical methods have been discussed.67, 86, 87, 88, 107
Toxicology of PCBâs
Long ago, toxicity of PCBâs to humans was recognized as causing yellow atrophy of the liver in fatal cases, dermatitis, and fatty degeneration of the liver in chronic exposure.14 Threshold limit values of 0.5 and 1 mg/m3 for PCBâs containing 42 and 54% chlorine, respectively, were established for industrial environments.97
In 1966, the discovery of PCBâs in environmental samples spurred renewed interest in the toxicity of PCBâs and a mass of information on the acute and chronic toxicity of PCBâs to a variety of animals has been obtained since then. Most of the studies were carried out using commercial PCB preparations and very little is known about the toxicity of individual chlorobiphenyls.
PCBâs accumulate in living matter, particularly in tissues and organs rich in lipids. The accumulation appears to be higher in the case of penta- and more highly chlorinated biphenyls. Tetra and less chlorinated biphenyls are hydroxylated and excreted (see Chapter 7). The toxicity of PCBâs varies a great deal from species to species, probably as a result of differences in metabolic rates and capabilities, physiological differences, etc. Thus, PCBâs are more toxic to some aquatic invertebrates than to fish and more toxic to salmon eggs than to juvenile Atlantic salmon. Chicken eggs may fail to hatch if they contain a high concentration of PCBâs and mink fail to reproduce when fed a PCB-contaminated diet. In humans, the appearance of symptoms of PCB poisoning was observed after the consumption of approximately 0.5 g of PCBâs in rice oil.
The mechanism of the toxic action of PCBâs is not know...
Table of contents
- Cover
- Title Page
- Copyright Page
- Table of Contents
- Chapter 1 Introduction
- Chapter 2 Commercial PCB Preparations: Properties and Compositions
- Chapter 3 Synthesis of Chlorobiphenyls
- Chapter 4 Other Biphenyl Syntheses
- Chapter 5 Chemical Reactions of Chlorobiphenyls
- Chapter 6 Photodegradation of Chlorobiphenyls
- Chapter 7 Metabolism of Chlorobiphenyls
- Chapter 8 Mass Spectrometry of Chlorobiphenyls
- Chapter 9 Nuclear Magnetic Resonance Spectroscopy of Chlorobiphenyls
- Chapter 10 Ultraviolet Spectroscopy of Chlorobiphenyls
- Chapter 11 Infrared Spectrometry of Chlorobiphenyls
- Chapter 12 Determination of PCBâs
- Chapter 13 Recent Developments
- Index