- 542 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Chromatographic Methods Development
About This Book
This book is a comprehensive compilation of modern and cutting-edge chromatographic techniques written by pharmaceutical industry experts, academics, and vendors in the field. This book is an inclusive guide to developing allchromatographic methods
(such as liquid chromatography and gas chromatography). It covers modern techniques for developing methods using chromatographic development software, requirements for validations, discussion on orthogonality, and how to transfer methods from HPLC to UHPLC. The text introduces some newer techniques that are heavily employed by chemists analyzing proteins and RNAi, as well as novel techniques such as counter current chromatography. This book is valuable for both the novice starting out in undergraduate labs and those who are new to the pharmaceutical industry and is a useful reference for seasoned analysts.
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Table of contents
- Cover
- Half Title Page
- Series Page
- Title Page
- Copyright Page
- Table of Contents
- Preface
- Â 1. A Lesson Learned from UHPLC
- Â 2. Software for Chromatographic Methods Development
- Â 3. Flash Chromatography Method Development
- Â 4. Orthogonality in Chromatographic Methods
- Â 5. Unified Approach to Reversed-Phase and Normal-Phase Chromatographic Method Development
- Â 6. Polysaccharide-Derived Chiral Stationary Phases for the Separation of Enantiomers
- Â 7. Chiral Chromatography: Method Development
- Â 8. Aqueous Normal-Phase Chromatography Using Type C Silica Columns
- Â 9. Ion Chromatography Columns
- 10. Ion Chromatography: Method Development
- 11. Fundamentals, Properties, and Applications of Stationary Phases for Gas Chromatography Method Development
- 12. Gas Chromatography Method Development
- 13. Method Transfer between HPLC and UHPLC
- 14. Small-Molecule Pharmaceutical Impurities Test Method Validation: Precision Acceptance Criterion
- 15. Method Development Strategies for Ion Exchange Chromatography Using pH Gradient Separation for mAbs, Antibody Drug Conjugates (ADCs) and Other Complex Bio-Pharmaceuticals
- 16. Size Exclusion Chromatography Method Development for Therapeutic Proteins
- 17. Countercurrent Chromatography Using Biphasic Molecular Liquids and Ionic Liquids: Is This the Future for Laboratory and Process Purifications?
- Index