Basic Pharmacokinetics
eBook - PDF

Basic Pharmacokinetics

  1. 595 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Basic Pharmacokinetics

Book details
Table of contents
Citations

About This Book

Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters.

After a basic introduction to pharmacokinetics and its related fields, the book examines:

  • Mathematical operations commonly used in pharmacokinetics
  • Drug distribution and clearance and how they affect the rate of drug elimination after a single dose
  • Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence
  • The steady-state concept during constant rate intravenous infusion and during multiple drug administration
  • Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion
  • Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling
  • Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics



Accompanying the book are downloadable resources with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.

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Information

Publisher
Routledge
Year
2012
ISBN
9781439850756
Edition
2
Topic
Medicine
Subtopic
Health Care Delivery

Table of contents

  1. Front Cover
  2. Contents
  3. Preface
  4. Author
  5. Chapter 1: Introduction to Pharmacokinetics
  6. Chapter 2: Review of Mathematical Fundamentals
  7. Chapter 3: Drug Pharmacokinetics Following a Single IV Bolus Administration : Drug Distribution
  8. Chapter 4: Drug Pharmacokinetics Following a Single IV Bolus Administration : Drug Clearance
  9. Chapter 5: Drug Pharmacokinetics Following a Single IV Bolus Administration : The Rate of Drug Elimination
  10. Chapter 6: Drug Absorption Following Extravascular Administration : Biological, Physiological, and Pathological Considerations
  11. Chapter 7: Drug Absorption Following Extravascular Administration : Molecular and Physicochemical Considerations
  12. Chapter 8: Drug Absorption Following Extravascular Administration : Formulation Factors
  13. Chapter 9: Drug Pharmacokinetics Following Single Oral Drug Administration : The Rate of Drug Absorption
  14. Chapter 10: Drug Pharmacokinetics Following Single Oral Drug Administration : The Extent of Drug Absorption
  15. Chapter 11: Bioequivalence
  16. Chapter 12: Drug Pharmacokinetics during Constant Rate IV Infusion : The Steady-State Principle
  17. Chapter 13: Steady State during Multiple Drug Administration
  18. Chapter 14: Renal Drug Excretion
  19. Chapter 15: Metabolite Pharmacokinetics
  20. Chapter 16: Nonlinear Pharmacokinetics
  21. Chapter 17: Multicompartment Pharmacokinetic Models
  22. Chapter 18: Drug Pharmacokinetics Following Administration by Intermittent Intravenous Infusion
  23. Chapter 19: Pharmacokinetic–Pharmacodynamic Modeling
  24. Chapter 20: Noncompartmental Approach in Pharmacokinetic Data Analysis
  25. Chapter 21: Physiological Approach to Hepatic Clearance
  26. Chapter 22: Physiologically Based Pharmacokinetic Models
  27. Chapter 23: Therapeutic Drug Monitoring
  28. Chapter 24: Pharmacokinetics in Special Patient Populations
  29. Chapter 25: Pharmacokinetic Drug–Drug Interactions
  30. Chapter 26: Pharmacogenetics : The Genetic Basis of Pharmacokinetic and Pharmacodynamic Variability
  31. Chapter 27: Applications of Computers in Pharmacokinetics
  32. Chapter 28: The Companion CD
  33. Solutions for the Practice Problems
  34. Back Cover