MICHAEL J. THORPY
Sleep disorders have had a formal classification since 1979, when the Association of Sleep Disorder Centers published the Classification of Sleep and Arousal Disorders in the journal Sleep.1 In 2013, the revised version of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) included a section entitled āSleep Wake Disorders,ā an update of the DSM-IV section (Table 1.1).2 This produced a classification for mental health and general medical clinicians who are not experts in sleep medicine. The classification differs from that of the International Classification of Sleep Disorders (ICSD-3) that was produced by the American Academy of Sleep Medicine and updated in 2014 (Table 1.2).3 The presence of two current competing classifications is not ideal, as it can cause confusion with health insurance companies and for epidemiological research. The International Classification of Diseases modified versionāthe ICD-10-CM (Table 1.3)āwill be adopted in the United States in 2016 and contains a classification that more closely conforms to the ICSD-3.4
DSM-V
Insomnia disorder, the first entry in the DSM-V (Table 1.1), is a diagnostic entry that requires the presence of at least one sleep complaint such as difficulty initiating sleep that must be present at least 3 nights per week for at least 3 months. The diagnosis is coded along with other mental, medical, and sleep disorders. The diagnosis can be specified as being episodic if it occurs for at least 1 month; however, acute and short-term insomnia, which have symptoms of less than 3 months, should be coded as āother specified insomnia disorder.ā
Hypersomnolence disorder requires a 3-month history of excessive sleepiness in the presence of significant distress or other impairment. Objective documentation by electrophysiological tests, such as the multiple sleep latency test (MSLT), is not required. This diagnosis is coded along with any other concurrent mental, medical, and sleep disorder. Narcolepsy is defined as recurrent episodes of sleep that occur for at least 3 months along with one of three additional features, such as cataplexy, hypocretin deficiency, or polysomnographic features, either a sleep-onset rapid eye movement period (SOREMP) on a nighttime polysomnogram (PSG) or an MSLT that shows a mean sleep latency of 8 minutes or less and two or more SOREMPs. So narcolepsy can be diagnosed in DSM-V if just sleepiness occurs for 3 months and there is a SOREMP on the nocturnal PSG. This has the potential for leading to errors in diagnosis, as other disorders, including obstructive sleep apnea syndrome (OSA), can produce similar features. Five subtypes of narcolepsy are specified according to: without cataplexy but with hypocretin deficiency; with cataplexy but without hypocretin deficiency; autosomal dominant cerebellar ataxia, deafness and narcolepsy; autosomal dominant narcolepsy, obesity and type 2 diabetes; or secondary to another medical condition.
Table 1.1 DSM-V
Sleepāwake disorders |
⢠Insomnia disorder |
⢠Hypersomnolence disorder |
⢠Narcolepsy |
⢠Subtypes: |
ā Without cataplexy but with hypocretin deficiency |
ā With cataplexy but without hypocretin deficiency |
ā Autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCADN) |
ā Autosomal dominant narcolepsy, obesity and type 2 diabetes (ADNOD) |
ā Secondary to another medical condition |
⢠Obstructive sleep apnea syndrome |
⢠Central sleep apnea |
⢠Sleep-related hypoventilation |
⢠Subtypes: |
ā Idiopathic hyperventilation |
ā Congenital central alveolar hypoventilation |
ā Comorbid sleep-related hypoventilation |
⢠Circadian rhythm sleep disorders |
⢠Delayed sleep phase type |
⢠Advance sleep phase type |
⢠Irregular sleepāwake type |
⢠Non-24-hour sleepāwake type |
⢠Shift work disorder |
⢠Unspecified type |
⢠Parasomnias |
⢠Non-rapid eye movement sleep arousal disorder |
ā Subtypes: Sleepwalking type Sleep terror type |
ā Nightmare disorder |
ā Rapid eye movement sleep behavior disorder |
⢠Restless legs syndrome |
⢠Substance/medication-induced sleep disorder |
⢠Other specified insomnia disorder |
⢠Other specified hypersomnolence disorder |
⢠Unspecified sleepāwake disorder |
⢠Unspecified insomnia disorder |
⢠Unspecified hypersomnolence disorder |
⢠Unspecified sleepāwake disorder |
Source: Adapted from American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V). Washington, DC: American Psychiatric Association, 2013.
OSA consists of an apnea hypopnea index (AHI) of at least 5 per hour, along with typical nocturnal respiratory symptoms, or daytime excessive sleepiness or fatigue. Alternatively, the diagnosis requires an AHI of at least 15, regardless of accompanying symptoms. Mild OSA is regarded as having an AHI of less than 15, moderate 15ā30, and severe greater than 30. Central sleep apnea (CSA) requires the presence of five or more central apneas per hour of sleep. Sleep-related hypoventilation has PSG evidence of decreased ventilation with either elevated CO2 levels or persistent oxygen desaturation unassociated with apneic/hypopneic events. Subtypes of sleep-related hypoventilation include idiopathic hypoventilation, congenital central alveolar hypoventilation, and comorbid sleep-related hypoventilation.
Circadian rhythm sleepāwake disorders (CRSWDs) with five subtypes is caused by a persistent recurrent pattern of sleep disruption due to an alteration or misalignment of the endogenous circadian rhythm and the individualās required sleepāwake schedule, along with symptoms of either insomnia or excessive sleepiness or both. Subtypes are delayed sleep phase type, advanced sleep phase type, irregular sleepāwake type, non-24-hour sleepāwake type, and shift work type, none of which have specifi...