Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" alon
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Animal Models in Toxicology
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- English
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- Available on iOS & Android
eBook - PDF
Animal Models in Toxicology
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1
CHAPTER
1
Introduction
Shayne
Cox
Gad
BACKGROUND
The.
use.
of.
animals.
in.
experimental.
medicine,.
pharmacology,.
pharmaceutical.
and.
medical.
device.development,.safety.assessment,.and.toxicological.evaluation.is.a.well-established,.regulato-
rily.required,.and.essential.practice
.
.Whether.serving.as.a.source.of.isolated.organelles,.cells,.or.tis-
sues,.a.disease.model,.or.a.predictive.model.for.drug.or.other.xenobiotic.action.or.transformation.in.
man,.animal.models.have.provided.the.necessary.building.blocks.that.have.permitted.the.explosive.
growth.of.medical.and.biological.knowledge.in.the.later.half.of.the.twentieth.century.and.into.the.
CONTENTS
Background.
........................................................................................................................................
1
Current.Animal.Studies.
.....................................................................................................................
2
Origins.of.Predictive.Animal.Testing.
................................................................................................
3
“Lash.Lure”.Case.
..........................................................................................................................
3
Elixir.of.Sulfanilamide.Case.
........................................................................................................
3
Thalidomide.
..................................................................................................................................
3
Selecting.an.Animal.Model.
...............................................................................................................
5
Husbandry.and.Care.
..........................................................................................................................
6
Caging.
...........................................................................................................................................
6
Choosing.Species.and.Strains.
............................................................................................................
7
Dosing.
................................................................................................................................................
7
Animal.Physiology.
.............................................................................................................................
8
Background.Incidence.of.Disease.and.Neoplasia.
.........................................................................
8
Responses.to.Biologically.Active.Agents.
......................................................................................
8
Absorption,.Distribution,.Metabolism,.and.Excretion.of.Xenobiotics.
.........................................
9
Absorption.
..............................................................................................................................
10
Distribution.
.............................................................................................................................
10
Metabolism.
.............................................................................................................................
11
Excretion.
................................................................................................................................
12
Summary.
..........................................................................................................................................
16
References.
........................................................................................................................................
16
Table of contents
- Front Cover
- Contents
- Preface
- Editor
- Contributors
- Chapter 1: Introduction
- Chapter 2: The Mouse
- Chapter 3: The Rat
- Chapter 4: The Hamster
- Chapter 5: The Guinea Pig
- Chapter 6: The Rabbit
- Chapter 7: The Ferret
- Chapter 8: The Dog
- Chapter 9: Primates
- Chapter 10: The Minipig
- Chapter 11: Alternative Species
- Chapter 12: Clinical Pathology of Laboratory Animals
- Chapter 13: Telemetry in Nonclinical Drug Safety Assessment Studies
- Chapter 14: Molecular Imaging Techniques in Laboratory Animals
- Chapter 15: Genetically Modified Animal Models
- Chapter 16: Model Selection and Scaling (Allometry)
- Chapter 17: Susceptibility Factors
- Chapter 18: Laws, Regulations, and Guidelines for Animal Care and Use in Research
- Chapter 19: Necropsy and Gross Pathology
- Chapter 20: Immunology Laboratory Endpoints for Assessment of Immunomodulators in Preclinical Studies and Case Studies Using Anti-CD3 mAb in Cynomolgus Monkey
- Appendix: Contact Information
- Back Cover
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Yes, you can access Animal Models in Toxicology by Shayne C. Gad, Shayne C. Gad,Shayne C. Gad, Shayne C. Gad, Shayne C. Gad in PDF and/or ePUB format, as well as other popular books in Medicine & Medical Theory, Practice & Reference. We have over one million books available in our catalogue for you to explore.