- 1,040 pages
- English
- PDF
- Available on iOS & Android
About This Book
Highlighting the latest activities and initiatives of prominent organizations working in the vaccine industry such as the Bill and Melinda Gates Foundation, The Global Alliance for Vaccines and Immunization, WHO, UNICEF, the World Bank, New Generation Vaccines, Fourth Edition, details steps developing countries have taken toward research, development, manufacture, and regulation of several new vaccines for widespread use.
This text will:
cover the current state-of-the-art techniques in vaccine development – including the successes and the failures
trace vaccine development from the bench to public health with regard to both FDA and European Union regulations
investigate improved methods for immunizing large populations, and the use of needless vaccinations
discuss the advancements in the heavily government-funded areas for developing vaccines against potential bioterror and infectious disease agents as well as the immunization of large population bases for diseases like: Anthrax, Smallpox, Ebola, West Nile, SARS, and others
Updated throughout with new cutting-edge information on recent breakthroughs and developments.
NEW TO GENERATION VACCINES, FOURTH EDITION:
highlights the latest activities of prominent organizations in the vaccine industry
covers the current techniques in vaccine development
investigates improved methods for immunizing large populations
Frequently asked questions
Information
Table of contents
- Front Cover
- Foreword
- Preface
- Contents
- Contributors
- Chapter 1. Vaccines and Vaccination in Historical Perspective
- Chapter 2. Developing Vaccines in the Era of Reverse Vaccinology
- Chapter 3. Initial Clinical Evaluation of New Vaccine Candidates
- Chapter 4. Special Issues in Performing Vaccine Trials in Developing Countries
- Chapter 5. Long-Term Evaluation of Vaccine Performance: Methodological Issues for Phase III and Phase IV Studies
- Chapter 6. Ethical Considerations in the Conduct of Vaccine Trials in Developing Countries
- Chapter 7. Vaccine Economics: Assuring That Vaccines Are Developed for and Available in Developing Countries
- Chapter 8. Development and Supply of Vaccines: An Industry Perspective
- Chapter 9. Reaching Every Child: Achieving Equity in Global Immunization
- Chapter 10. A Paradigm for International Cooperation: The GAVI Alliance
- Chapter 11. Economic Analyses of Vaccines and Vaccination Programs
- Chapter 12. An Overview of U.S. Food and Drug Administration Licensure of Vaccines
- Chapter 13. Assuring Vaccine Quality by Strengthening Regulatory Agencies: The Work of the World Health Organization
- Chapter 14. Vaccine Safety
- Chapter 15. Manufacturing of Vaccines
- Chapter 16. Polio Eradication: Ongoing Innovation to End an Ancient Scourge
- Chapter 17. Recent Advances in Immunology That Impact Vaccine Development
- Chapter 18. Modulting Vaccine Responses with Innate Immunity
- Chapter 19. Immunodominance, Deveptive Imprinting, and Immune Refocusing Technology
- Chapter 20. Standardization and High-Throughput Measurement of T-Cell Responses to Vaccines
- Chapter 21. Transition to High-Throughput Laboratory Assays to Evaluate Multivalent Vaccines
- Chapter 22. The Challenge of Vaccine Protection in Very Young Infants
- Chapter 23. The Challenge of Inducing Vaccine Protection in the Elderly
- Chapter 24. Vaccination and Autoimmunity
- Chapter 25. Adjuvants for the Future
- Chapter 26. TLF9 Agonists for Immune Enhancement of Vaccines
- Chapter 27. Use of Genetically or Chemically Detoxified Mutants of Cholera and Escherichia coli Heat-Labile Enterotoxins as Mucosal Adjuvants
- Chapter 28. Recent Developments in Nonliving Antigen Delivery Systems
- Chapter 29. Virus-Like Particles as Vaccines and Vaccine Delivery Systems
- Chapter 30. Subunit Vaccines Produced Using Plant Biotechnology
- Chapter 31. Lipopeptide-Based Vaccines
- Chapter 32. Vaccines Based on Dendritic Cell Biology
- Chapter 33. Vaccinia Virus and Other Poxviruses as Live Vectors
- Chapter 34. Replication-Defective and Competent Adenovirus Recombinants as Vaccine Vectors
- Chapter 35. RNA Virus Replicon Vaccines
- Chapter 36. Engineering of Attenuated Salmonella enterica Serovars for Use as Live Vector Vaccines
- Chapter 37. DNA Vaccines
- Chapter 38. Overview of Heterologous Prime-Boost Immunization Strategies
- Chapter 39. Mucosal Immunization and Needle-Free Injection Devices
- Chapter 40. Advances in Transcutaneous Vaccine Delivery
- Chapter 41. Rationalizing Childhood Immunization Programs: The Variation in Schedules and Use of Combination Vaccines
- Chapter 42. Meningococcal Conjugate and Protein-Based Vaccines
- Chapter 43. Post-Licensure Impact of Haemophilus influenzae Type b and Serogroup C Neisseria meningitidis Conjugate Vaccines in Industrialized Countries
- Chapter 44. Haemophilus influenzae Type b Disease Burden and the Impact of Programmatic Infant Immunization in Developing Countries
- Chapter 45. Pneumococcal Protein-Polysaccharide Conjugate Vaccines
- Chapter 46. Pneumococcal Common Proteins and Other Vaccine Strategies
- Chapter 47. Polysaccharide-Based Conjugate Vaccines for Enteric Bacterial Infections: Typhoid Fever, Nontyphoidal Salmonellosis, and Escherichia coli O157:H7
- Chapter 48. Attenuated Strains of Salmonella enterica Serovars Typhi and Paratyphi as Live Oral Vaccines Against Enteric Fever
- Chapter 49. Oral Cholera Vaccines
- Chapter 50. Novel Vaccines Against Tuberculosis
- Chapter 51. Influenza
- Chapter 52. Chimeric Vaccines Against Japanese Encephalitis, Dengue, and West Nile
- Chapter 53. Vaccines Against Rotavirus Gastroenteritis
- Chapter 54. Novel Strategies for Immunizing Infants in Developing Countries Who Are Too Young to Receive the Currently Licensed Measles Vaccines
- Chapter 55. Challenges and Prospects for the Development of an HIV Vaccine
- Chapter 56. Vaccine Strategies to Prevent Dengue
- Chapter 57. Vaccination Against the Hepatitis C Virus
- Chapter 58. Vaccines Against Respiratory Syncytial Virus and Parainfluenza Viruses
- Chapter 59. Cytomegalovirus Vaccines
- Chapter 60. Epstein-Barr Virus Vaccines
- Chapter 61. Herpes Simplex Vaccines
- Chapter 62. Development of Vaccines to Prevent Group A Streptococcal Infections and Rheumatic Fever
- Chapter 63. Vaccines Against Group B Streptococcus
- Chapter 64. Overview of Live and Subcellular Vaccine Strategies Against Shigella
- Chapter 65. Vaccines Against Enterotoxigenic Escherichia coli
- Chapter 66. Multivalent Shigella Enterotoxigenic Escherichia coli Vaccine
- Chapter 67. Vaccines for Staphylococcus aureus Infections
- Chapter 68. Chlamydia trachomatis Vaccines
- Chapter 69. Malaria Vaccines in Clinical Development: Introduction and Recombinant/Subunit Approaches
- Chapter 70. Gene-Based Malaria Vaccines
- Chapter 71. Pre-erythrocytic and Asexual Erythrocytic Stage Whole-Organism Malaria Vaccines
- Chapter 72. Vaccines Against Leishmania
- Chapter 73. Vaccines Against Schistosomiasis
- Chapter 74. Vaccines Against Entamoeba histolytica
- Chapter 75. Hookworm Vaccines
- Chapter 76. Improved Smallpox Vaccines
- Chapter 77. Anthrax Vaccines
- Chapter 78. Tularemia Vaccines
- Chapter 79. Vaccines Against Plague
- Chapter 80. Development of Vaccines for Ebola and Marburg Viruses: Efficacy and Regulatory Considerations
- Chapter 81. Therapeutics and Vaccines Against Hendra and Nipah Viruses
- Chapter 82. Vaccines Against Lassa Fever
- Chapter 83. Hantavirus Vaccines
- Chapter 84. SARS Vaccines
- Chapter 85. Cancer-Specific Vaccines
- Chapter 86. Vaccines Against Human Papillomaviruses
- Chapter 87. Vaccines Against Alzheimer's and Other Neurodegenerative Diseases
- Chapter 88. Vaccination for Autoimmune and Other Chronic Inflammatory Disorders
- Chapter 89. Immunotherapies To Treat Drug Addiction
- Index
- Back Cover