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- 600 pages
- English
- PDF
- Available on iOS & Android
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This book comprehensively accounts the current understanding of genetic mechanisms of obesity by analyzing obesity phenotypes and genotypes and, gene polymorphisms and mutations, and current results from animal model research and genetic studies in human models. By presenting the impact of genetic factors in the development of obesity and key molec
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Yes, you can access Obesity by Karine Clement, Thorkild I. A. Sorensen in PDF and/or ePUB format, as well as other popular books in Medicine & Medical Theory, Practice & Reference. We have over one million books available in our catalogue for you to explore.
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Table of contents
- Front cover
- Preface
- Contents
- Contributors
- Introduction
- Section 1: Obesity Phenotype
- Chapter 1.1 Human Phenotypes
- Section 2: Quantitative Genetics of Obesity
- Chapter 2.1 Family Studies
- Chapter 2.2 Adoption Studies
- Chapter 2.3 Twin Studies
- Chapter 2.4 Experimental Twin Studies
- Chapter 2.5 Commingling and Segregation Analyses
- Section 3: Rodent Models of Obesity
- Chapter 3.1 Natural Monogenic Models
- Chapter 3.2 Transgenic Models Targeting the Central Nervous System
- Chapter 3.3 Transgenic Models in the Periphery
- Chapter 3.2 Natural Polygenic Models
- Section 4: Nonvertebrate Models
- Chapter 4.1 Will Fatty Worms or Flies Help Discover the Mechanism of Human Obesity?
- Section 5: Syndromic and Monogenic Human Obesity
- Chapter 5.1 Overview of Human Monogenic, Nonsyndromic, and Syndromic Obesity
- Chapter 5.2 Prader-Willi Syndrome
- Chapter 5.3 Bardet-Biedl Syndrome: New Insights into Ciliopathies and Oligogenic Traits
- Chapter 5.4 Leptin and Leptin Receptor Mutations
- Chapter 5.5 POMC and PC1 Mutations
- Chapter 5.6 MC4R Mutations
- Section 6: Polygenic Human Obesity
- Chapter 6.1 Overview of Genetic Studies in Polygenic Obesity and Methodological Challenges
- Chapter 6.2 Genome-Wide Approaches
- Chapter 6.3 Association and Linkage Studies in Caucasians
- Section 7: Gene-Environment Interaction in Human Obesity
- Chapter 7.1 Genetics of Eating Behavior
- Chapter 7.2 Genetics of Physical Activity
- Chapter 7.3 Interaction Between Genes and Lifestyle Factors
- Chapter 7.4 Genetics and Hormonal Changes
- Chapter 7.5 Genetics and Drugs
- Section 8: Epigenetics in Obesity
- Chapter 8.1 Molecular Basis of Epigenetic Memory
- Chapter 8.2 Implications for Obesity and Common Diseases
- Section 9: Tissue and Organ-Specific Gene Function
- Chapter 9.1 Genes Regulating Adipose-Tissue Development and Function
- Chapter 9.2 Genetics of Adipose-Tissue Development and Function in Humans
- Chapter 9.3 Nutritional Regulation of Adipocyte Differentiation
- Chapter 9.4 Genes Involved in Muscle Function
- Chapter 9.5 Genes Involved in Gut and Brain Dialogue
- Section 10: Omics Technology and System Biology
- Chapter 10.1 Introduction to Omics Platforms
- Chapter 10.2 Analysis and Data Integration
- Chapter 10.3 Transcriptomics Results
- Chapter 10.4 Proteomics and Metabonomics Routes Toward Obesity
- Chapter 10.5 Quantitative Proteomics for Analysis of Adipocyte Development and Function
- Section 11: Conclusion
- Chapter 11.1 Exciting Advances and New Opportunities
- Index
- Back cover