Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes--as well as parallel issues shaping the pharmaceutical industry--to promote the next generation of safer, more effective drugs. Topics include dioxygen activation, the identification and characterization of metabolites, bioactivation, P450 in lab animal species, enzyme kinetics, reaction phenotyping, drug-drug interactions, pharmacogenetics, hepatic clearance, and the role of UGTs.

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Yes, you can access Drug Metabolizing Enzymes by Jae Lee, R. Scott Obach, Michael B. Fisher in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.

Information

Publisher

CRC Press

Year

2003

ISBN

9781420028485

Edition

Topic

Medicine

Subtopic

Pharmacology

Front Cover
Contents
Editor's Preface
Foreword
1. Dioxygen Activation by Cytochromes P450: A Role for Multiple Oxidants in the Oxidation of Substrates
2. Application of LC/MS, LC/NMR, NMR and Stable Isotopes in Identifying and Characterizing Metabolites
3. Bioactivation
4. Chemically Reactive Metabolites in Drug Discovery and Development
5. Cytochrome P450 and its Place in Drug Discovery and Development
6. Cytochrome P450 in Laboratory Animal Species
7. Typical and Atypical Enzyme Kinetics
8. Cytochrome P450 Reaction Phenotyping
9. Drug-Drug Interactions and the Cytochromes P450
10. CYP Gene Induction by Xenobiotics and Drugs
11. Cytochrome P450 Pharmacogenetics
12. Role of Intestinal Cytochromes P450 in Drug Disposition
13. Prediction of Hepatic Clearance in Humans from Experimental Animals and In Vitro Data
14. Non-P450 Mediated Oxidative Metabolism of Xenobiotics
15. The Role of Sulfotransferases (SULTs) and UDP-GlucuronosyItransferases (UGTs) in Human Drug Clearance and Bioactivation
Index