Introduction
Antisocial behaviors refers to a heterogeneous set of actions outside the norms, rules, or laws of the social group in which the subject develops, such as physical aggression, theft, and violation of societal rules. Such behaviors may have a number of medical and social implications (Nau, 2005). For example, in France, a review ordered by the National Medical Research Institute in 2006 (Institut National de la Santé et de la Recherche Médicale, France, 2006) sparked an intense debate in the medical and scientific fields. The discussions focused on the use of early predictors for antisocial behaviors, which was interpreted by some to be a source of social stigma of at-risk populations as well as a determinist interpretation of disadvantaged populations (Ehrenberg, 2006; Lenoble, E., Malika, B.-B., Sandrine, C., & Forget, J.-M., 2006).
In daily practice, clinicians are often requested by families or institutions to be involved in caring for children and adolescents with antisocial or defiant behaviors when first-line educational interventions fail.
It is important to take into account that exhibiting some antisocial behavior such as lying or theft is often considered the norm for children; however, such expressions are generally limited in time and number. For example, a peak in physical aggression is observed at age 3 in both boys and girls, with an expected decline following the emergence of the child's socioemotional skills (Tremblay, 2002). Antisocial behaviors can be seen in almost all contexts of psychopathology in children and adolescents, from a maladaptive reaction to stressful family situations to its episodic expression during an acute psychiatric episode (e.g., depressive episode, mania, or psychotic episode). Children who exhibit persistent and repetitive antisocial behaviors are defined in international classifications as having conduct disorders (CD).
The prevalence of CD in children and adolescents is high (2.7%–5.2%) and both crises and life trajectories of these children and adolescents are difficult to manage for families, institutions, and themselves (Costello, Mustillo, Erkanli, Keeler, & Angold, 2003; Kessler et al., 2012).
The first study on the natural course of antisocial behaviors from childhood to adulthood was conducted by Robins (Robins, 1966). She examined at age 30 years 406 people who had been referred to a child guidance center at age 13 years. All subjects who had committed serious offenses in adulthood had shown antisocial behaviors in childhood. Among the outcomes in adulthood, 12% of youths with antisocial behavior had complete remission, 27% had partial improvement (more than three antisocial symptoms), and 61% remained unimproved in adulthood. Since this seminal work, a large amount of empirical data highlighted the assumption that the persistence of antisocial behaviors throughout the life span is a main risk for youths with CD. A systematic review reported that 40%–70% of youths with CD evolve into having an antisocial personality disorder in adulthood (R.J.R. Blair, 2015; National Collaborating Centre for Mental Health (UK) & Social Care Institute for Excellence (UK), 2013). When antisocial behaviors persist in adulthood, they are associated with dramatically elevated morbidity and mortality. For this group, the risk of premature death at age 40 is 33 times higher than that for the general population (Black, Baumgard, Bell, & Kao, 1996). Young adults with antisocial problems are at particular risk for trauma, sexually transmitted infections, and toxic-related infections (hepatitis C virus and HIV). Compliance with managing a medical problem (such as epilepsy) is often problematic and access to care services is chaotic (Black & Donald, 2015).
The need to develop effective interventions to reduce antisocial behaviors in childhood has become increasingly recognized by public health policy makers. In addition to preventive programs in the general population, the development of targeted prevention interventions for specific subgroups of youths is seen as an important approach. This requires a better understanding of the variety of pathways into and out of antisocial behaviors throughout the life span, and a definition of relevant subgroups of patients. In the early 1990s, Moffit (T.E. Moffitt, 1993) suggested that the onset of difficulties may differentiate groups of patients with distinct trajectories of antisocial behaviors, i.e., life course–persistent disorder (LCP) and adolescent-limited (AL) conduct problems. Another distinction was made with regard to the presence of prosocial emotions. Considering the vast number of studies addressing these questions, an updated review of this topic is needed.
This chapter synthesizes the studies on the variability of clinical expression and trajectories into and out of antisocial behaviors from a developmental point of view. First, we will describe how antisocial behaviors are categorized in the international classifications and how these classifications differentiate clinical subtypes and trajectories of antisocial behaviors. Second, we show how comorbidities are associated with different trajectories of antisocial behaviors. Then, we will consider the neuropsychological characteristics associated with specific pathways of antisocial behaviors. Finally, genetic and neurobiological factors involved in these trajectories are discussed.