In Vivo Models to Study Angiogenesis

Domenico Ribatti

• Publisher: Academic Press
• Year: 2017
• ISBN:
  9780128140215
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available.

Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling.

• Provides information on the most common assays to study angiogenesis in vivo
• Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development
• Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Introduction
• Chapter 1. The Chick Embryo Chorioallantoic Membrane
• Chapter 2. The Corneal Assay for Angiogenesis
• Chapter 3. The Matrigel Implant Assay
• Chapter 4. The Sponge Implant Model
• Chapter 5. The Disk Angiogenesis System
• Chapter 6. The Dorsal Air Sac Model
• Chapter 7. The Chamber Assays
• Chapter 8. The Zebrafish
• Chapter 9. Animal Tumor Models
• Concluding Remarks