Aneurysms-Osteoarthritis Syndrome: SMAD3 Gene Mutations is a first-of-its-kind compilation of the genetic discovery, research, and care associated with AOS. With the field of genetically triggered aortopathies growing, this important reference will compile the newest discoveries in this field, allowing cardiologists, cardio-thoracic surgeons, clinical geneticists, vascular surgeons, orthopedic surgeons, and researchers to gain the knowledge they need without having to gather the data from various sources.

Coverage includes genotype and phenotype correlations, the functional role of SMAD3, and insights into the role of TGFbeta signaling in aortic disease. The book will increase knowledge about AOS, providing awareness and better patient care for this aggressive disease.

Covers Aneurysms-Osteoarthritis Syndrome, from genetic discovery to patient care
Contains clinical management guidance on optimal cardiovascular treatments and surgery
Explains the autosomal dominant syndromes caused by mutations in the SMAD3 gene
Identifies the key features of this syndrome, including arterial aneurysms and tortuosity, early onset arthritis, and mild craniofacial features

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Yes, you can access Aneurysms-Osteoarthritis Syndrome by Denise van der Linde,Jolien Roos-Hesselink,Bart L. Loeys in PDF and/or ePUB format, as well as other popular books in Medicina & Ortopedia. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Elsevier

Year

2016

ISBN

9780128027110

Topic

Medicina

Subtopic

Ortopedia

Cover
Title page
Table of Contents
Copyright
List of Contributors
Preface
Chapter 1: Genetics of Aneurysms-Osteoarthritis Syndrome
Chapter 2: Cardiovascular Phenotype of Aneurysms-Osteoarthritis Syndrome
Chapter 3: Systemic Features of Aneurysms-Osteoarthritis Syndrome
Chapter 4: Differential Diagnosis in Heritable Thoracic Aortic Diseases
Chapter 4a: Marfan Syndrome
Chapter 4b: Loeys-Dietz Syndrome
Chapter 4c: Ehlers-Danlos Syndrome
Chapter 4d: Bicuspid Aortic Valve
Chapter 4e: Turner Syndrome
Chapter 5: Cardiovascular Imaging in Aneurysm-Osteoarthritis Syndrome
Chapter 6: Treatment Options
Chapter 6a: Optimal Cardiovascular Medical Treatment
Chapter 6b: Cardiothoracic Surgical Experience
Chapter 6c: Vascular Interventions and Surgical Experience
Chapter 6d: Orthopedic Evaluation and Treatment Options
Chapter 6e: Genetic Counseling
Chapter 6f: Approach to Clinical Management
Index