Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

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Yes, you can access Molecular Biology of B Cells by Tasuku Honjo,Michael Reth,Andreas Radbruch,Frederick Alt,Michael Neuberger in PDF and/or ePUB format, as well as other popular books in Medicine & Immunology. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Academic Press

Year

2004

ISBN

9780080479507

Topic

Medicine

Subtopic

Immunology

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1: Human Immunoglobulin Heavy Chain Locus
Chapter 2: Immunoglobulin Heavy Chain Genes of Mouse
Chapter 3: Immunoglobulin κ Genes of Human and Mouse
Chapter 4: Immunoglobulin Lambda (IGL) Genes of Human and Mouse
Chapter 5: The Mechanism of V(D)J Recombination
Chapter 6: Transcription of Immunoglobulin Genes
Chapter 7: Early B Cell Development to a Mature, Antigen-Sensitive Cell
Chapter 8: Allelic Exclusion, Isotypic Exclusion, and the Developmental Regulation of V(D)J Recombination
Chapter 9: The Development of Human B Lymphocytes
Chapter 10: Development and Function of B Cell Subsets
Chapter 11: Structure and Function of B Cell Antigen Receptor Complexes
Chapter 12: Regulation of Antigen Receptor Signaling by the Co-Receptors, CD19 and CD22
Chapter 13: The Dynamic Structure of Antibody Responses
Chapter 14: Dynamics of B Cell Migration to and within Secondary Lymphoid Organs
Chapter 15: Characteristics of Mucosal B Cells with Emphasis on the Human Secretory Immune System
Chapter 16: The Cellular Basis of B Cell Memory
Chapter 17: Immunoglobulin Assembly and Secretion
Chapter 18: Fc and Complement Receptors
Chapter 19: Regulation of Class Switch Recombination
Chapter 20: Molecular Mechanism of Class Switch Recombination
Chapter 21: Molecular Mechanism of Hypermutation
Chapter 22: Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody
Chapter 23: Chromosomal Translocations in B-Cell Leukemias and Lymphomas
Chapter 24: Classification and Characteristics of Mouse B Cell—Lineage Lymphomas
Chapter 25: B Cells Producing Pathogenic Autoantibodies
Chapter 26: Immunodeficiencies Caused by B-Cell Defects
Chapter 27: Diverse Forms of Immunoglobulin Genes in Lower Vertebrates
Chapter 28: Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT
Chapter 29: The Zebrafish Immune System
Chapter 30: The Origin of V(D)J Diversification
Chapter 31: Antibody Structure and Recognition of Antigen
Chapter 32: Monoclonal Antibodies from Display Libraries
Chapter 33: Humanization of Monoclonal Antibodies
Chapter 34: Human Monoclonal Antibodies from Translocus Mice
Index