Epigenetic Gene Expression and Regulation

Suming Huang, Michael D. Litt, C. Ann Blakey

• Publisher: Academic Press
• Year: 2015
• ISBN:
  9780128004715
• Topic: Scienze biologiche
• Subtopic: Biologia molecolare

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies.

The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.

The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.

Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.

• Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies
• Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring
• Chapters are replete with clinical examples to empower the basic biology with translational significance
• Offers more than 100 illustrations to distill key concepts and decipher complex science

Table of contents

• Cover image
• Title page
• Table of Contents
• Translational Epigenetics Series
• Copyright
• Contributors
• Preface
• Acknowledgment
• Chapter 1. Epigenetic gene expression—an introduction
• Chapter 2. Histone modifications—models and mechanisms
• Chapter 3. Genomic imprinting in mammals—memories of generations past
• Chapter 4. Polycomb and Trithorax factors in transcriptional and epigenetic regulation
• Chapter 5. Chromatin dynamics and genome organization in development and disease
• Chapter 6. ncRNA function in chromatin organization
• Chapter 7. Epigenetic gene regulation and stem cell function
• Chapter 8. Epigenetic inheritance
• Chapter 9. Transgenerational epigenetic regulation by environmental factors in human diseases
• Chapter 10. Identification of intergenic long noncoding RNA by deep sequencing
• Chapter 11. Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA
• Chapter 12. Genetically altered cancer epigenome
• Chapter 13. Long noncoding RNAs and carcinogenesis
• Chapter 14. Epigenetics of physiological and premature aging
• Chapter 15. Epigenetic effects of environment and diet
• Chapter 16. Epigenetic control of stress-induced apoptosis
• Chapter 17. Structure, regulation, and function of TET family proteins
• Chapter 18. Epigenetic drugs for cancer therapy
• List of acronyms and abbreviations
• Glossary
• Index