- 518 pages
- English
- ePUB (mobile friendly)
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Molecular Genetics of Sex Determination
About This Book
In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation.
With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students.
- Reviews the genetics of sex determination in 19 up-to-date chapters
- Features research on sex chromosomes and sex-determining genes
- Includes abnormalities of sex determination and clinical genetics
- Written by scientists who pioneered work in this field
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Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: The Search for the Male-Determining Gene
- Chapter 2: The Cloning of SRY
- Chapter 3: The Mouse Y Chromosome
- Chapter 4: XX Sex Reversal in the Mouse
- Chapter 5: XY Sex Reversal in the Mouse
- Chapter 6: Conservation of the X-Linkage Group in Toto by All Eutherian Mammals
- Chapter 7: X-Chromosome Inactivation
- Chapter 8: Sex Determination in Marsupials and Monotremes
- Chapter 9: The Feminine Mystique: The Initiation of Sex Determination in Drosophila
- Chapter 10: The Human Y Chromosome
- Chapter 11: DNA Sequence Homology between the Human Sex Chromosomes
- Chapter 12: XX Sex Reversal in the Human
- Chapter 13: XY Sex Reversal in the Human
- Chapter 14: Phenotypic Correlations of X-Chromosome Loss
- Chapter 15: Molecular Genetics of Androgen Insensitivity Syndromes in Humans
- Chapter 16: Male Pseudohermaphroditism
- Chapter 17: Molecular Genetics of Steroid 21-Hydroxylase Deficiency
- Chapter 18: The Gene for Anti-MĂźllerian Hormone
- Chapter 19: MĂźllerian-Inhibiting Substance: Critical Roles in Sexual Differentiation
- Index