eBook - PDF

The Mouse in Biomedical Research

Immunology

392 pages
English
PDF
Available on iOS & Android

eBook - PDF

The Mouse in Biomedical Research

Immunology

Book details

Table of contents

Citations

About This Book

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

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Information

Publisher

Academic Press

Year

2006

ISBN

9780080469089

Edition

Topic

Biological Sciences

Subtopic

Zoology

Index

Biological Sciences

Front Cover
The Mouse in Biomedical Research: Immunology
Copyright Page
Table of Contents
List of Reviewers
List of Contributors
Foreword
Preface
Overview
Chapter 1. The Molecular Basis of Lymphoid Architecture in the Mouse
Chapter 2. The Biology of Toll-Like Receptors in Mice
Chapter 3. Genomic Organization of the Mouse Major Histocompatibility Complex
Chapter 4. Some Biological Features of Dendritic Cells in the Mouse
Chapter 5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes
Chapter 6. Mouse Natural Killer Cells: Function and Activation
Chapter 7. Cytokine-Activated JAK-STAT Signaling in the Mouse Immune System
Chapter 8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
Chapter 9. Mouse Models of Negative Selection
Chapter 10. Peripheral Tolerance of T Cells in the Mouse
Chapter 11. The Genetics of Mouse Models of Systemic Lupus
Chapter 12. Inhibitory Receptors and Autoimmunity in the Mouse
Chapter 13. Mouse Models of Immunodeficiency
Chapter 14. Mouse Models to Study the Pathogenesis of Allergic Asthma
Chapter 15. The Mouse Trap: How Well Do Mice Model Human Immunology?
Index
Colour Plates