The Chemistry and Pharmacology of Taxol® and its Derivatives
eBook - PDF

The Chemistry and Pharmacology of Taxol® and its Derivatives

H. Timmerman, V. Farina

  1. 338 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

The Chemistry and Pharmacology of Taxol® and its Derivatives

H. Timmerman, V. Farina

Book details
Table of contents
Citations

About This Book

Taxol®, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers.

The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discussed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and pharmacokinetics of Taxol® are also discussed, as are the chemistry of taxanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms of resistance.

The book is therefore written for medical chemists, in order to stimulate further research in this area and to provide the reader with the necessary background information to start a research program in the area.

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Information

Publisher
Elsevier Science
Year
1995
ISBN
9780080544991
Topic
Medicine
Subtopic
Pharmacology

Table of contents

  1. Front Cover
  2. The Chemistry and Pharmacology of Taxol® and its Derivatives
  3. Copyright Page
  4. Contents
  5. List of contributors
  6. Preface
  7. Chapter 1. Naturally Occurring Taxoids
  8. Chapter 2. The Structural Elucidation of Taxoids
  9. Chapter 3. Paclitaxel (Taxol®) Formulation and Prodrug
  10. Chapter 4. Metabolism and Pharmacology of Taxoids
  11. Chapter 5. Paclitaxel (Taxol®) Chemistry and Structure Activity Relationship
  12. Chapter 6. The Chemistry of the Taxol®) Side Chain Synthesis, Modifications and Conformational Studies
  13. Chapter 7. The Biochemical Pharmacology of Taxol®)and Mechanisms of Resistance
  14. Subject Index
Citation styles for The Chemistry and Pharmacology of Taxol® and its Derivatives

APA 6 Citation

Timmerman, H. (1995). The Chemistry and Pharmacology of Taxol® and its Derivatives ([edition unavailable]). Elsevier Science. Retrieved from https://www.perlego.com/book/1842186/the-chemistry-and-pharmacology-of-taxol-and-its-derivatives-pdf (Original work published 1995)

Chicago Citation

Timmerman, H. (1995) 1995. The Chemistry and Pharmacology of Taxol® and Its Derivatives. [Edition unavailable]. Elsevier Science. https://www.perlego.com/book/1842186/the-chemistry-and-pharmacology-of-taxol-and-its-derivatives-pdf.

Harvard Citation

Timmerman, H. (1995) The Chemistry and Pharmacology of Taxol® and its Derivatives. [edition unavailable]. Elsevier Science. Available at: https://www.perlego.com/book/1842186/the-chemistry-and-pharmacology-of-taxol-and-its-derivatives-pdf (Accessed: 15 October 2022).

MLA 7 Citation

Timmerman, H. The Chemistry and Pharmacology of Taxol® and Its Derivatives. [edition unavailable]. Elsevier Science, 1995. Web. 15 Oct. 2022.