Practical Process Research and Development

Neal G. Anderson

• Publisher: Academic Press
• Year: 2000
• ISBN:
  9780080514482
• Topic: Biological Sciences
• Subtopic: Science Research & Methodology
• Index: Biological Sciences

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students.

• Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules"
• Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more
• Includes over 100 tips for rapid process development
• Presents guidelines for implementing and troubleshooting processes

Table of contents

• Front Cover
• Practical Process Research & Development
• Contents
• Foreword by K. Barry Sharpless
• Foreword by Jerome L. Moniot
• Preface
• About the Author
• Chapter 1. Approaches to Process Development
• Chapter 2. Route Selection
• Chapter 3. Reagent Selection
• Chapter 4. Solvent Selection
• Chapter 5. Running the Reaction
• Chapter 6. Effects of Water
• Chapter 7. In-Process Controls
• Chapter 8. Optimizing the Reaction by Minimizing Impurities
• Chapter 9. Optimizing Catalytic Reactions
• Chapter 10. Work-up
• Chapter 11. Tools for Purifying the Product: Column Chromatography, Crystallization, and Reslurrying
• Chapter 12. Final Product Form and Impurity Considerations
• Chapter 13. Vessels and Mixing
• Chapter 14. Preparing for and Implementing the Scale-up Run
• Chapter 15. Troubleshooting
• Chapter 16. Chiral Syntheses
• General Index
• Reaction Type Index
• Reagent Index