Studies in Natural Products Chemistry

Stereoselective Synthesis

Atta-ur Rahman

• Publisher: Elsevier
• Year: 2013
• Print ISBN:
  9780444893666
• eBook ISBN:
  9781483193243
• Topic: Physical Sciences
• Subtopic: Inorganic Chemistry

Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.

Table of contents

• Front Cover
• Stereoselective Synthesis (Part H)
• Copyright Page
• Table of Contents
• FOREWORD
• PREFACE
• CONTRIBUTORS
• PART 1: Stereoselective Synthesis
• Chapter 2. A New Tandem Process and its Application to the Synthesis of Macrolide Antibiotics
• Chapter 3. Stereoselective Synthetic and Mechanistic Chemistry of Bicyclomycin
• Chapter 4. The Role of Isocyanides in the Synthesis of β-Lactam Antibiotics and Related Compounds
• Chapter 5. Synthesis of the lβ-Methylcarbapenem Key Intermediates Yoshio Ito and Shiro Terashima
• Chapter 6. Chemical Studies of the Taxane Diterpenes Charles S. Swindell
• Chapter 7. Recent Advances in the synthesis of Tumor-Promoting Diterpenes
• Chapter 8. Hydroxylated Indolizidines and their Synthesis
• Chapter 9. A Survey of Indolo [2,3-a] carbazole Alkaloids and Related Natural Products
• Chapter 10. Synthetic Methodology for 2-Amino Alcohols of Biological Interest
• Chapter 11. Stereoselective Synthesis of Natural Products via Cationicand Radical Intermediates
• SUBJECT INDEX