- 540 pages
- English
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About This Book
Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.
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Table of contents
- Front Cover
- Stereoselective Synthesis (Part H)
- Copyright Page
- Table of Contents
- FOREWORD
- PREFACE
- CONTRIBUTORS
- PART 1: Stereoselective Synthesis
- Chapter 2. A New Tandem Process and its Application to the Synthesis of Macrolide Antibiotics
- Chapter 3. Stereoselective Synthetic and Mechanistic Chemistry of Bicyclomycin
- Chapter 4. The Role of Isocyanides in the Synthesis of β-Lactam Antibiotics and Related Compounds
- Chapter 5. Synthesis of the lβ-Methylcarbapenem Key Intermediates Yoshio Ito and Shiro Terashima
- Chapter 6. Chemical Studies of the Taxane Diterpenes Charles S. Swindell
- Chapter 7. Recent Advances in the synthesis of Tumor-Promoting Diterpenes
- Chapter 8. Hydroxylated Indolizidines and their Synthesis
- Chapter 9. A Survey of Indolo [2,3-a] carbazole Alkaloids and Related Natural Products
- Chapter 10. Synthetic Methodology for 2-Amino Alcohols of Biological Interest
- Chapter 11. Stereoselective Synthesis of Natural Products via Cationicand Radical Intermediates
- SUBJECT INDEX