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- 120 pages
- English
- PDF
- Available on iOS & Android
eBook - PDF
The Na+, K+ Pumps Keep Us Going
Book details
Table of contents
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About This Book
Every second throughout life, billions of sodium-potassium pumps enable the human muscle cells to function. The pump is an enzyme found in the plasma membrane of all animal cells and is an important example of active transport. The Na+, K+-pumps keep us going by pumping sodium out of cells while pumping potassium into cells and without them, we would not survive. Addressed to specialists in the field of biomedicine, the author presents a thorough overview of his scientific results over more than 40 years. The book is richly illustrated and seeks to explain how a single molecule creates the required conditions for our muscles to work.
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Yes, you can access The Na+, K+ Pumps Keep Us Going by Torben Clausen in PDF and/or ePUB format, as well as other popular books in Medicine & Medical Theory, Practice & Reference. We have over one million books available in our catalogue for you to explore.
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Topic
MedicineTable of contents
- Cover
- Titlepage
- Colophon
- Table of Contents
- Preface
- The Na+, K+ pump and its discovery
- The Transport and distribution of Na+ and K+ in skeletal muscle and how they are quantified
- Rapid passive fluxes of Na+ and K+ start muscle contraction and set a limit to excitability
- The definition, structure and function of the Na+, K+-pump
- The synthesis and localization of the Na+, K+ pumps in skeletal muscle
- Measurements of the content of [3H]ouabain binding sites indicate that in skeletal muscle, the major part of these binding sites of the Na+, K+ pumps are localized on the outer surface of sarcolemma and in the t-tubules
- The content of Na+, K+ pumps in skeletal muscles and how it can be quantified
- Muscle contractions, Na+, K+ transport and sodium potassium fatigue
- The rate of [3H]ouabain binding to sarcolemma can be quantified and what information may this provide?
- Measurements of [3H]ouabain binding to other cell types and preparations
- Acute and long-term regulation of Na+, K+ pumps in skeletal muscle
- Catecholamines and caffeine
- Peptide hormones stimulating the Na+, K+pumps
- Insulin-like growth Factor-I (IGF-I)
- CGRP and other calcitonins
- Amylin, related peptides, and other stimuli for the Na+, K+-pumps
- The importance of Na+-influx in causing depolarization and muscle fatigue
- Effect of varying Na+, K+-pump stimulating agents on intracellular Na+ in rat soleus muscles and how this may compensate functional defects caused by plasma membrane leakage
- Long-Term Regulation of Na+, K+ Pump Content
- Training, inactivity and denervation
- Muscular dystrophy and McArdle disease
- Hyperkalemic periodic paralysis in horses, human subjects and mutant mice with a similar genetic anomaly
- K+ deficiency and K+ restoration
- Thyroid hormones and starvation
- Thermogenic actions of thyroid hormones and malignant hyperthermia (MH)
- Diabetes
- Steroid hormones, Glucocorticoids, Aldosterone
- Major Conclusions and General Perspectives
- References