Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally 'difficult to target' proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

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Yes, you can access Protein Degradation with New Chemical Modalities by Hilmar Weinmann, Craig Crews, Hilmar Weinmann, Craig Crews in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Royal Society of Chemistry

Year

2020

ISBN

9781839160776

Edition

Topic

Medicine

Subtopic

Pharmacology

Cover
Half Title
Series Information
Title Page
Copyright Page
Preface
Contents
Chapter 1 PROTAC-mediated Target Degradation: A Paradigm Changer in Drug Discovery?
Chapter 2 Structural and Biophysical Principles of Degrader Ternary Complexes
Chapter 3 Immediate and Selective Control of Protein Abundance Using the dTAG System
Chapter 4 Developing Pharmacokinetic/Pharmacodynamic Relationships With PROTACs
Chapter 5 New Activities of CELMoDs, Cereblon E3 Ligase-modulating Drugs
Chapter 6 Structure-based PROTAC Design
Chapter 7 Plate-based High-throughput Cellular Degradation Assays to Identify PROTAC Molecules and Protein Degraders
Chapter 8 PROTAC Targeting BTK for the Treatment of Ibrutinib-resistant B-cell Malignancies
Chapter 9 An Efficient Approach Toward Drugging Undruggable Targets
Chapter 10 E3-mediated Ubiquitin and Ubiquitin-like Protein Ligation: Mechanisms and Chemical Probes
Chapter 11 Plant E3 Ligases as Versatile Tools for Novel Drug Development and Plant Bioengineering
Chapter 12 Deubiquitinase Inhibitors: An Emerging Therapeutic Class
Chapter 13 Targeting Translation Regulation for the Development of Novel Drugs
Chapter 14 Classes, Modes of Action and Selection of New Modalities in Drug Discovery
Chapter 15 Small-molecule Targeted Degradation of RNA
Index