Challenges in Endocrine Disruptor Toxicology and Risk Assessment

Alberto Mantovani, Alexandra Fucic, Alberto Mantovani, Alexandra Fucic

• Publisher: Royal Society of Chemistry
• Year: 2020
• ISBN:
  9781839160837
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Chemistry
• Index: Chemistry

Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer's disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Table of contents

• Cover
• Half Title
• Title
• Copyright
• Preface
• Contents
• Section 1 – Endocrine Disruptor: Mechanisms and Effects
• Chapter 1 Endocrine Disruptor Effects on Estrogen, Androgen and Thyroid Pathways: Recent Advances on Screening and Assessment
• Chapter 2 Epigenetic Reprogramming by Endocrine Disrupting Chemicals
• Chapter 3 Issues for Hazard Characterization of Endocrine Disrupting Chemicals: The Use of Adverse Outcome Pathways
• Chapter 4 Integrated Translation Framework for Endocrine Disruptors in the area of Computational Toxicology
• Chapter 5 Sex-specific Actions of Endocrine Disruptors
• Chapter 6 Health Risks of Transplacental Exposure to Endocrine Disruptors
• Chapter 7 Endocrine Disruptors and Cancer: From Genotoxicity Mechanisms to Ethnicity-related Susceptibility
• Chapter 8 Bone as a Target for Endocrine Disruptors
• Chapter 9 Pathways of ED-induced Neuro-developmental Disturbances: An Overview
• Chapter 10 Vitamin A and the Retinoid System – From Nutrition to Endocrine Disruption
• Chapter 11 Linking Ecohealth and One Health approaches. A Case Study on the EU Water Framework Directive Strategy About Alkylphenols in Aquatic Ecosystems
• Chapter 12 Pollution of Water and Food by Hormonally Active Pesticides and Drugs (Human and Veterinary): Focus on Emerging Countries: Emerging Contaminants with Endocrine Disruption Potential in Brazil
• Chapter 13 Pollution of Food and Water by Hormonally Active Pesticides and Veterinary Drugs Residues: Focus on Sub Saharan African Countries
• Chapter 14 Natural Substances in Supplements and Nutraceuticals as Endocrine Disruptors
• Chapter 15 Endocrine Disruptors in Building Materials
• Chapter 16 Endocrine Disrupting Chemicals in Clothing and Cosmetics
• Chapter 17 Challenges in Endocrine Disruptor Toxicology and Risk Assessment
• Chapter 18 Biomarkers of Effect for EDCs and Indicators to be Used in Epidemiological Studies on Reproductive Health
• Chapter 19 Occupational Exposure to Endocrine Disruptors and Reproductive Health
• Chapter 20 Interdisciplinary Collaboration between Environmental Health and Clinical Experts on Cancers and Infertility Associated with Exposure to Endocrine Disruptors
• Chapter 21 Regulation and Risk Management of Endocrine Disruptors: Current Status and Future Perspectives
• Subject Index