Pediatric Solid Organ Transplantation

Richard N. Fine, Steven A. Webber, William E. Harmon, Deirdre A. Kelly, Kim M. Olthoff, Richard N. Fine, Steven A. Webber, William E. Harmon, Deirdre A. Kelly, Kim M. Olthoff

• Publisher: Wiley-Blackwell
• Year: 2009
• Print ISBN: 9781405124072
• eBook ISBN: 9781444312737
• Edition: 2
• Topic: Medicine
• Subtopic: Public Health, Administration & Care

Pediatric Solid Organ Transplantation is a comprehensive and succinct text on all aspects of pediatric solid organ transplantation. It provides a ready source of reference, to both the basic science and organ specific surgical technique and after care. This second edition has been extensively updated in light of recent developments in this rapidly advancing area.

The only textbook devoted to the field of pediatric transplantation

• A definitive reference for all those interested in improving the care and quality of life of children undergoing solid organ transplantation
• Section on immunosuppression has been expanded by four chapters to include sections on;
  - mechanisms of action
  - therapies for the sensitized patient
  - post-transplant lymphoproliferative disorders
  - organ toxicities of immunosuppressive therapy
• A new section has been added on the many topics related to quality of life that effect survivors of pediatric transplantation
• International editorial and contributor team represents a wide geographical range and contains both recognized leaders and emerging experts

Whether you are an established sub-specialist in pediatric transplantation, a transplant surgeon, or a pediatric specialist in a related area, this book will answer all your questions about care of the pediatric patient before, during, and after transplantation.

Table of contents

• Preface to the Second Edition
• Preface to the First Edition
• Contributors
• Section 1 Immunology and Genetics
• 1 The Immune Response to Organ Allografts
• 2 Allorecognition Pathway
• 3 Costimulation
• 4 The HLA System and Histocompatibility Testing for Organ Transplantation
• 5 Gene Polymorphisms and Pharmacogenomics
• 6 Genomics and Proteomics as Research Tools
• 7 Tolerance: A Review its Mechanisms in the Transplant Setting
• Section 2 Immunosuppression and its Complications
• 8 Mechanisms of Action of Immunosuppressive Agent
• 9 Induction and Maintenance Immunosuppression
• 10 Novel Immunosuppressants
• 11 Therapies for the Allosensitized Patien
• 12 Infections Post-Transplantation
• 13 Post-Transplant Lymphoproliferative Disorders and Malignancy
• 14 Organ Toxiciti
• Section 3 Kidney Transplantation
• 15 Historical Note
• 16 Recipient Characteristics
• 17 Evaluation of the Candidate
• 18 Donor Evaluation, Surgical Technique and Perioperative Management
• 19 Pathology of the Kidney Allograft
• 20 Post-Transplant Management
• 21 Outcomes and Risk Factors
• Section 4 Liver Transplantation
• 22 Historical Notes
• 23 Recipient Characteristics
• 24 Evaluation of the Candidate
• 25 Donor Evaluation, Surgical Technique and Perioperative Management
• 26 Pathology of the Liver Allograft
• 27 Post-Transplant Management
• 28 Outcomes and Risk Factors
• Section 5 Heart Transplantation
• 29 Historical Notes
• 30 Recipient Characteristics
• 31 Evaluation of the Candidate
• 32 Donor Evaluation, Surgical Technique and Perioperative Management
• 33 Pathology of the Cardiac Allograft
• 34 Post-Transplant Management
• 35 Outcomes and Risk Factors
• Section 6 Lung and Heart-Lung Transplantation
• 36 Historical Notes
• 37 Recipient Characteristics
• 38 Evaluation of the Candidate
• 39 Donor Evaluation, Surgical Technique and Perioperative Management
• 40 Pathology of the Lung Allograft
• 41 Post-Transplant Management
• 42 Outcomes and Risk Factors
• Section 7 Intestinal Transplantation
• 43 Historical Notes
• 44 Recipient Characteristics
• 45 Evaluation of the Candidate
• 46 Donor Evaluation, Surgical Technique and Perioperative Management
• 47 Pathology of the Intestinal Allograft
• 48 Post-Transplant Management
• 49 Outcomes and Risk Factors
• Section 8 Special Issues after Pediatric Transplantation
• 50 Growth and Puberty
• 51 Cognitive Development
• 52 Psychosocial Adaptation and Adherence
• 53 Pregnancy
• 54 Gynecologic Issues
• 55 Transition to Adult Care
• Index