Advances in Cancer Signal Transduction and Therapy

Manoj K. Pandey, Vijay P. Kale

• Publisher: Bentham Science Publishers
• Year: 2020
• ISBN:
  9789811458118
• Topic: Medicine
• Subtopic: Oncology

Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level.These changes drive normal cells to proliferate and escape processes thatusually regulate their survival and migration. Many of these alterations areoften associated with signaling pathways which regulate cell growth anddivision, cell death, survival, invasion and metastasis, and angiogenesis.Almost all cancer cells show high expression of signaling components includinggrowth factor receptor tyrosine kinases (RTKs), small GTPases, serine/threoninekinases, cytoplasmic tyrosine kinases, lipid kinases, estrogen receptor, activation of transcription factors Myc and NF-?B, etc. Updated knowledge aboutthese signaling components is highly desirable for researchers involved indeveloping therapies against cancer.Signal TransductionResearch for Cancer Therapy covers advancements in research on the signalingpathways in the human body, especially in some types of cancers, such asbreast cancer, pancreatic cancer and colon cancer. Keyfeatures of this volume include 8 focused topical reviews on signaling pathwaysin a specific cancer type, coverage of multiple cancer types (breast cancer, colon cancer, hepatocellular cancer, multiple myeloma, acute myeloid leukemia, and pancreatic cancer), and coverage of a wide array of signaling pathways (bothreceptor mediated and non receptor mediated pathways). Thisvolume is essential reading for researchers in pharmaceutical R&D andpostgraduate research programs in pharmacology and allied disciplines.Clinicians involved in oncology will also benefit from the information providedin the chapters.

Table of contents

• Welcome
• Table of Content
• Title
• BENTHAM SCIENCE PUBLISHERS LTD.
• PREFACE
• LIST OF CONTRIBUTORS
• Wnt Signaling in Breast Cancer Oncogenesis, Development and Progression
• CXCR4 Signaling and its Impact on Tumor Progression and Metastasis in Breast Cancer
• Epidermal Growth Factor Receptor Signaling in Colon Cancer
• Targeting the PI3K/AKT/mTOR Signaling Pathway in Hepatocellular Carcinoma: Current State and Future Trends
• MAPK Signaling Pathway: A Central Target in Pancreatic Cancer Therapeutics
• Role of NF-κB Activation in Multiple Myeloma and Other Hematological Malignancies
• Bruton’s Tyrosine Kinase Signaling and Advancement in Multiple Myeloma Therapy
• The Tumor Microenvironment Mediated Signaling Pathways in the Progression of Acute Myeloid Leukemia