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Information

Year
2022
ISBN
9780841297326

Table of contents

  1. Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry. Volume 4
  2. ACS Symposium Series1423
  3. Foreword
  4. Preface
  5. Discovery and Chemical Development of Uvelostinag (MK-1454): A Therapeutic Cyclic Dinucleotide Agonist of the Stimulator of Interferon Gene
  6. Discovery and Chemical Development of Adafosbuvir, a Nucleoside Phosphoramidate Prodrug for the Treatment of Hepatitis C Infection
  7. Discovery and Development of a Highly Potent, Orally Bioavailable Estrogen Receptor Full Antagonist and Degrader: Giredestrant (GDC-9545) for Estrogen Receptor-Positive Breast Cancer
  8. A Twisted Road to the Discovery and Chemical Development of BMS-986142: A Reversible Inhibitor of BTK Conformationally Constrained by Two Rotationally Stable Atropisomeric Axes
  9. Discovery of AMG 232, a Small Molecule Disrupting the p53-MDM2 Protein–Protein Interaction and Development of a Validation-Ready Process for Its Manufacture
  10. The Discovery and Chemical Development of BMS-986251: A Selective RORγt Inverse Agonist for the Potential Treatment of Autoimmune Diseases
  11. Discovery and Chemical Development of Amcenestrant: An Oral Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer
  12. Development and Optimization of the Manufacturing Process for RNA-Splicing Modifier Risdiplam RG7916
  13. Past, Present, and Future: A Changing Paradigm for Process Chemistry
  14. Editors’ Biographies
  15. Indexes
  16. Author Index
  17. Subject Index
  18. Preface
  19. Discovery and Chemical Development of Uvelostinag (MK-1454): A Therapeutic Cyclic Dinucleotide Agonist of the Stimulator of Interferon Gene
  20. Discovery and Chemical Development of Adafosbuvir, a Nucleoside Phosphoramidate Prodrug for the Treatment of Hepatitis C Infection
  21. Discovery and Development of a Highly Potent, Orally Bioavailable Estrogen Receptor Full Antagonist and Degrader: Giredestrant (GDC-9545) for Estrogen Receptor-Positive Breast Cancer
  22. A Twisted Road to the Discovery and Chemical Development of BMS-986142: A Reversible Inhibitor of BTK Conformationally Constrained by Two Rotationally Stable Atropisomeric Axes
  23. Discovery of AMG 232, a Small Molecule Disrupting the p53-MDM2 Protein–Protein Interaction and Development of a Validation-Ready Process for Its Manufacture
  24. The Discovery and Chemical Development of BMS-986251: A Selective RORγt Inverse Agonist for the Potential Treatment of Autoimmune Diseases
  25. Discovery and Chemical Development of Amcenestrant: An Oral Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer
  26. Development and Optimization of the Manufacturing Process for RNA-Splicing Modifier Risdiplam RG7916
  27. Past, Present, and Future: A Changing Paradigm for Process Chemistry
  28. Editors’ Biographies
  29. Indexes
  30. Author Index
  31. Subject Index