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Handbook for Chemical Process Research and Development, Second Edition
Wenyi Zhao
- 826 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Handbook for Chemical Process Research and Development, Second Edition
Wenyi Zhao
About This Book
This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies.
Features:
- This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner.
- Promotes an industrial mindset concerning safety and commercial viability when developing methods.
- The author discusses development strategies with case studies and experimental procedures.
- Focuses on mechanism-guided process development which provides readers with practical strategies and approaches.
- Addresses more common process issues such as safety, cost, robustness, and environmental impact.
This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.
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Table of contents
- Cover
- Half-Title
- Title
- Copyright
- Contents
- Preface
- Author Biography
- List of Abbreviations
- Chapter 1âReaction Solvent Selection
- Chapter 2âReagent Selection
- Chapter 3âVarious Reagent Surrogates
- Chapter 4âModes of Reagent Addition: Control of Impurity Formation
- Chapter 5âProcess Optimization with Additives
- Chapter 6âProcess Optimization of Catalytic Reactions
- Chapter 7âProcess Optimization of Problematic Reactions
- Chapter 8âHazards of Oxidation and Reduction Reactions
- Chapter 9âOther Hazardous Reactions
- Chapter 10âHazardous Reagents
- Chapter 11âGrignard Reagent and Related Reactions
- Chapter 12âChallenging Reaction Intermediates
- Chapter 13âProtecting Groups
- Chapter 14âTelescope Approach
- Chapter 15âDesign of New Synthetic Route
- Chapter 16âStereochemistry
- Chapter 17âVarious Quenching Strategies
- Chapter 18âVarious Isolation and Purification Strategies
- Chapter 19âMethods for Residual Metal Removal
- Chapter 20âMethods for Impurity Removal
- Chapter 21âPharmaceutical Salts
- Chapter 22âSolid Form
- Index