Overcoming Ovarian Cancer Chemoresistance

Goli Samimi, Christina Annunziata

• Publisher: Academic Press
• Year: 2020
• Print ISBN:
  9780128198407
• eBook ISBN:
  9780128198414
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. - Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response - Discusses genetic reversions as a unique alteration and a new field of study - Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Cover Image Insert
• Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy”
• About the Series Editor
• Aims and Scope of Volume
• About the Volume Editors
• Preface
• Contributors
• Chapter 1: Epithelial ovarian cancer: Genomic landscape and evolving precision treatment
• Chapter 2: Overview of mechanisms of chemoresistance in ovarian cancer
• Chapter 3: The development of drug resistance through reversion mutation in BRCA genes in ovarian cancer
• Chapter 4: Ovarian cancer stem cell biology and chemoresistance
• Chapter 5: The use of immunotherapy for treatment of chemoresistant ovarian cancer
• Chapter 6: Models of ovarian cancer to test new agents
• Chapter 7: Novel agents to target treatment resistance in ovarian cancer
• Chapter 8: Promising agents on the horizon
• Index