Immunological Implications and Molecular Diagnostics of Genitourinary Cancer

Moulay Mustapha Ennaji

• Publisher: Academic Press
• Year: 2022
• Print ISBN:
  9780323854962
• eBook ISBN:
  9780323854979
• Topic: Medicina
• Subtopic: Immunologia

Immunological Implications and Molecular Diagnostics of Genitourinary Cancer updates on recent accomplishments, unifying concepts, and future challenges in the study of tumor-associated immune cells, emphasizing genitourinary cancers. The presence of inflammatory immune cells in human tumors raise a fundamental question: How do cancer cells avoid destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells, however, as tumors develop from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms. This book covers research on the immunological implications of genitourinary cancer with a comprehensive view, especially surrounding diagnosis and cellular mechanisms. - Discusses the impact of the immune system on the initiation, progression and treatment of cancer - Provides insights on the important role of the suppressor genes and oncogenes in genitourinary cancers - Shows the advantages of combining clinical issues of urologic cancers with immunological techniques, like immunohistochemistry and immunofluorescence - Demonstrates the implications genitourinary cancer has on the human innate immune system

Table of contents

• Immunological Implications and Molecular Diagnostics of Genitourinary Cancer
• Chapter 1 Introduction to the molecular aspects and viral therapy of genitourinary tumors
• Chapter 2 Liquid biopsy of exosome markers for molecular diagnosis of genitourinary cancer
• Chapter 3 The molecular mechanism of novel oncogenes dysregulating signaling pathways associated with cervical carcinoma
• Chapter 4 Role of epigenetic factors in cancer progression induced by inactivation of tumor suppressors genes
• Chapter 5 Exosomes as diagnostic and prognostic tools in prostate cancer
• Chapter 6 Adenovirus vectors for vaccination and cancer gene therapy
• Chapter 7 Molecular diagnosis of human oncogenic viruses associated with prostate cancer: Human Papillomavirus and Epstein–Barr virus
• Chapter 8 Molecular characterization of oncogenic biomarkers associated with genitourinary cancers: the case of prostate cancer
• Chapter 9 Diagnostic screening of the microdeleation mutations in the azoospermia factor-gene cluster of the Y chromosome and; prostate cancer among Arabs: toward establishment of gene therapy platform in the region☆☆ In the Book: Genitourinary cancer: Molecular diagnostic immunological implications: genetic aspect and viral therapy.
• Chapter 10 Recent advances in high-risk human papillomavirus genotype relationship with bladder cancer tumor genesis
• Chapter 11 Tumor-associated macrophages in prostate cancer: role in progression and therapy
• Chapter 12 Emerging therapeutic targets of genitourinary tumors
• Chapter 13 Cell–cell differentiation induction: model for cervical cancer
• Chapter 14 The clinical significance of long noncoding RNAs expression in cervical cancers
• Chapter 15 Triple-negative breast cancer and its correlation with viral agents
• Chapter 16 Role of exosomes in bladder cancer diagnosis and therapy
• Chapter 17 Upper urinary tract urothelial cell carcinoma
• Chapter 18 Testicular cancer
• Chapter 19 A comprehensive survey on spectrum of BRCA1 and BRCA2 pathogenic variants in breast and ovarian cancer
• Chapter 20 Molecular and epidemiological characterization of bladder tumors
• Chapter 21 Impact of signaling in the development pathway of genitourinary cancers
• Chapter 22 Prostate cancer: genetic changes and viral-mediated immune regulation
• Chapter 23 Dramatic impact of partial loss of PTEN function on tumorigenesis and progression of prostate cancer
• Chapter 24 Association between glucose consumption and cancer development: prostate cancer and bladder cancer
• Chapter 25 Oncogenic human viruses associated with prostate cancer: molecular epidemiology of Human Papillomavirus and Epstein–Barr virus
• Chapter 26 Genitourinary cancers immune biomarkers: a comprehensive overview
• Chapter 27 The global genomic allelic heterogeneity of the HOXB 13 variants of prostate cancer and gene therapy application for different genealogical lineages of the Y-chromosome haplogroups and haplotypes of STR microsatellites
• Chapter 28 Impact of vitamin D status on breast cancer prognosis
• Index