Vaccinology and Methods in Vaccine Research

Rebecca Ashfield, Angus Nnamdi Oli, Charles Esimone, Linda Onyeka Anagu

• Publisher: Academic Press
• Year: 2022
• Print ISBN:
  9780323911467
• eBook ISBN:
  9780323914383
• Topic: Medicine
• Subtopic: Immunology

Vaccinology and Methods in Vaccine Research is a combination of cutting-edge methodologies, experimental approaches and literature reviews. The book covers all aspects of vaccine development, including basic immunology (focusing on the stimulation of adaptive immunity, which is required for vaccine efficacy), approaches to vaccine design and target validation, vaccine biomanufacturer and clinical development. Existing vaccinology resources are theoretical reference books, whereas this book provides a practical handbook for use in the research lab and classroom by those working in vaccinology and training others in the field. It is authored and edited by scientists actively engaged in vaccine research and development for day-to-day teaching/methodological advice. - Addresses how to design a vaccine for an emerging disease, from a practical point-of -view, with chapters written by scientists who are grappling with these questions - Provides new approaches to vaccine development. including vaccine targeting and virus-like-particle vaccines - Gives up-to-date information and methodologies in use for vaccine adjuvants

Table of contents

• Vaccinology and Methods in Vaccine Research
• Chapter 1 Immunology and the concept of vaccination
• Chapter 2 Vaccine types and reverse vaccinology
• Chapter 3 Dendritic cells as vaccine targets
• Chapter 4 Vaccine development: from the laboratory to the field
• Chapter 5 Harnessing the power of CD8+ T-cells: identification and validation of peptides bound to major histocompatibility complex class I by immunopeptidomics
• Chapter 6 Virus-like particle vaccines
• Chapter 7 Approaches to cancer vaccination
• Chapter 8 Vaccines against SARS-CoV-2
• Chapter 9 Adjuvants, immunomodulators, and adaptogens
• Chapter 10 GMP manufacture and quality control
• Chapter 11 Testing vaccines: essential steps in clinical trial design
• Index