Landmark Experiments in Protein Science

Pascal Leclair

• Publisher: CRC Press
• Year: 2023
• Print ISBN: 9781032458694
• eBook ISBN: 9781000897593
• Topic: Biological Sciences
• Subtopic: Biochemistry in Medicine
• Index: Biological Sciences

Proteins are the workhorses of cells, performing most of the important functions which allow cells to use nutrients and grow, communicate among each other, and importantly, die if aberrant behavior is detected. How were proteins discovered? What is their role in cells? How do dysfunctional proteins give rise to cancers? Landmark Experiments in Protein Science explores the manner in which the inner workings of cells were elucidated, with a special emphasis on the role of proteins. Experiments are discussed in a manner as to understand what questions were being asked that prompted the experiments and what technical challenges were faced in the process; and results are presented and discussed using primary data and graphs.

Key Features

• Describes landmark experiments in cell biology and biochemistry
• Discusses the "How" and "Why" of historically important experiments
• Includes primary, original data and graphs
• Emphasizes biological techniques, that help understand how many of the experiments performed were possible
• Documents, chronologically, how each result fed into the next experiments

Table of contents

• Cover Page
• Half-Title Page
• Title Page
• Copyright Page
• Dedication Page
• Contents
• Preface
• Acknowledgments
• About the Author
• Chapter 1 Prelude to Biology: A History of Chemistry
• Chapter 2 The Cell and Heredity
• Chapter 3 Discovery of Proteins and Enzymes
• Chapter 4 Protein and DNA Subunits
• Chapter 5 The Energy of Cells Part I: Glycolysis and the Krebs Cycle
• Chapter 6 Protein and DNA Structure
• Chapter 7 Protein Synthesis Part I: Localization of Protein Translation
• Chapter 8 Protein Synthesis Part II: The Mechanism of Protein Translation
• Chapter 9 The Energy of Cells Part II: Oxidative Phosphorylation
• Chapter 10 The Energy of Cells Part III: The Mechanism of ATP Synthesis
• Chapter 11 Techniques
• Chapter 12 Cell Signaling Part I: The Role of Phosphorylation
• Chapter 13 Cell Signaling Part II: G-protein-coupled Receptors
• Chapter 14 The Secretory Pathway
• Chapter 15 The Mechanism of Cell Death
• Chapter 16 The Biology of Cancer
• Index